Health Geography can provide a spatial comprehension of a population's health, the environment's effect on health and disease and the distribution of disease in an area. It also deals with accessibility to health care and spatial distribution of health care providers and diseases. In this paper, we elaborate the importance of GIS in the public health fields and the restraint that faced in the implementing of GIS. In addition, we also highlighted the potential of GIS in substance abuse management based on the reviewing other studies, including understanding the geographic distribution of substance abuse problems, risk area spatial accessibility to the treatment center, and network analysis and modelling. Despite the ability of GIS in handling these cases, certain limitations were identified to be obstacles of the application of this technology for substance abuse. For example, the GIS application requires high expertise and technical users to handle the system. Through the power of GIS analyses, it is capable in identifying the risk area, monitoring the substance abuse problems, planning the strategic program, and providing a systematic system to aide in decision-making processes.