Identification of Mamu-DPA1, Mamu-DQA1, and Mamu-DRA alleles in a cohort of Chinese rhesus macaques

Deng, Qi; Zhang, Huiling; Xiang, Ruirui; Zhang, Zhenwu; Ling, Fei; Zhuo, Min; Du, Hongli; Wang, Xiaoning

doi:10.1007/s00251-013-0736-3

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…DQ genes of MHC class II region encode for α (DQA) and β (DQB) chains of the molecule (NIRANJAN et al, 2010). The second exon has been shown to be highly polymorphic and under positive selection, and the class II DQA gene has recently attracted more attention (AMILLS et al, 2008;JUNYING et al, 2008;MIYASAKA et al, 2011;HOU et al, 2011;DENG et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Nucleotide sequence variability analysis of Major Histocompatibility Complex Class II DQA1 gene in Nigerian goats

et al. 2017

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Wheto and I. G. Imumorin (2017): Nucleotide sequence variability analysis of major histocompatibility complex class II DQA1 gene in Nigerian goats. Vol 49, No.3,[865][866][867][868][869][870][871][872][873][874] Major Histocompatibility Complex (MHC) molecules loaded with peptides derived from invading pathogens are recognised by the immune system to produce a highly effective and specific response against foreign pathogens. A 310-bp fragment of exon 2 of the MHC Class II DQA1 gene was amplified in 27 animals made up of three major Nigerian goat breeds [West African Dwarf (WAD), Red Sokoto (RS) and Sahel (SH)]. Twenty amino acid polymorphic sites were found in Nigerian goats. Comparison of predicted amino acid residues of DQA1 exon 2 alleles of Nigerian goats with similar alleles from other caprine species revealed considerable congruence in amino acid 866 GENETIKA, Vol. 49, No3, 865-874, 2017 substitution pattern. A significant positive selection signature was detected at the DQA1 locus of Nigerian goats in that non-synonymous substitutions occurred at a faster rate compared to synonymous substitutions (dN:dS ratio = 1.28 ; Z-Statistics= 1.634; P<0.05). The evolutionary tree constructed using UPGMA, revealed that the southern WAD goat appeared to be more related to the northern RS than SH goat at the DQA1 locus. It will be interesting therefore, for future studies to investigate the association of the genetic variants in DQA1 gene of Nigerian goats with resistance/susceptiblity to diseases in order to conserve these precious animal genetic resources.

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Section: Introductionmentioning

confidence: 99%

Nucleotide sequence variability analysis of Major Histocompatibility Complex Class II DQA1 gene in Nigerian goats

et al. 2017

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“…The orthologs of the human class II genes are present in macaques and are designated, respectively, Mamu-, Mafaand Mane-DR, -DQ, and -DP. Sequencing analyses have resulted in the description of about 450 class II alleles that are archived in the nonhuman primate section of the IPD-MHC database (Blancher et al 2014;Creager et al 2011;de Groot et al 2004;de Groot et al 2012;Deng et al 2013;Karl et al 2014;Otting et al 2012). However, most of these studies focused only on exon 2 sequences, which encode the antigen-binding region of the proteins (Doxiadis et al 2006;Ling et al 2011;Sano et al 2006).…”

Section: Introductionmentioning

confidence: 99%

The orthologs of HLA-DQ and -DP genes display abundant levels of variability in macaque species

et al. 2016

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The human major histocompatibility complex (MHC) region encodes three types of class II molecules designated HLA-DR, -DQ, and -DP. Both the HLA-DQ and -DP gene region comprise a duplicated tandem of A and B genes, whereas in macaques, only one set of genes is present per region. A substantial sequencing project on the DQ and DP genes in various macaque populations resulted in the detection of previously 304 unreported full-length alleles. Phylogenetic studies showed that humans and macaques share trans-species lineages for the DQA1 and DQB1 genes, whereas the DPA1 and DPB1 lineages in macaques appear to be species-specific. Amino acid variability plot analyses revealed that each of the four genes displays more allelic variation in macaques than is encountered in humans. Moreover, the numbers of different amino acids at certain positions in the encoded proteins are higher than in humans. This phenomenon is remarkably prominent at the contact positions of the peptide-binding sites of the deduced macaque DPβ-chains. These differences in the MHC class II DP regions of macaques and humans suggest separate evolutionary mechanisms in the generation of diversity.

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“…The MHC-DRA gene is considered to be conserved in mammalian species, such as the DRA gene across the cattle species [ 5 , 6 ]. However, the gene has been cloned and sequenced in many other species with some variations reported: Chinese rhesus macaques [ 7 ], donkeys [ 8 ], equine [ 9 ] and sheep [ 10 ] in which allelic diversity of DRA is found to be higher than that reported in other vertebrates. Currently, 13 DRA alleles of swine have been recorded in the Immune Polymorphism Database (IPD)-SLA ( ), while only 6 DRA alleles of cattle and 11 DRA alleles of ovine are recorded.…”

Section: Introductionmentioning

confidence: 99%

Effect of Genetic Diversity in Swine Leukocyte Antigen-DRA Gene on Piglet Diarrhea

Huang

Yang

Yuan

et al. 2016

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The swine leukocyte antigens (SLAs) are the multigene families related to immune responses. Little is known about the effect of the DRA gene on diarrheal disease. This study reported the genetic diversity of the DRA gene in exons 1, 3 and 4 in 290 Chinese Yantai black pigs. No variation was identified in exon 3. In exon 1, three genotypes and two alleles were identified, generated by two single nucleotide polymorphisms (SNPs). In exon 4, there were eight genotypes and five alleles containing seven SNPs were detected with four SNPs being novel SNPs. The low polymorphism found in swine DRA is consistent with the concept that the DRA gene is highly conserved among all mammalian species. Statistical analyses indicated that the genotypes of exon 1 were not significantly associated with piglet diarrhea (p > 0.05); however, genotypes C4C4 (1.80 ± 0.33) and A4E4 (1.66 ± 0.25) of exon 4 were significantly susceptible to diarrhea (p < 0.01). These indicate that the particular genotypes of the DRA gene are susceptible to diarrheal disease, which provides valuable information for disease-resistance breeding in swine.

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Identification of Mamu-DPA1, Mamu-DQA1, and Mamu-DRA alleles in a cohort of Chinese rhesus macaques

Cited by 8 publications

References 15 publications

Nucleotide sequence variability analysis of Major Histocompatibility Complex Class II DQA1 gene in Nigerian goats

Nucleotide sequence variability analysis of Major Histocompatibility Complex Class II DQA1 gene in Nigerian goats

The orthologs of HLA-DQ and -DP genes display abundant levels of variability in macaque species

Effect of Genetic Diversity in Swine Leukocyte Antigen-DRA Gene on Piglet Diarrhea

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