Abstract:Lamins are components of the structural network in the nucleus and play a key role in nuclear organization and function. Mutations in the human lamin A gene cause a spectrum of genetic diseases that include muscular dystrophies, cardiomyopathy, lipodystrophy and premature ageing syndromes. Laminopathic cells display several abnormalities in nuclear morphology and function. We have carried out a comprehensive analysis of alterations in the protein profiles of HEK293T cells expressing a mutation in lamin A (Q294… Show more
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