2022
DOI: 10.1111/all.15498
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Identification of mast cell progenitor cells in the airways of individuals with allergic asthma

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Cited by 1 publication
(2 citation statements)
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“…50 Reductions in AHR with imatinib were noted without an associated effect on eosinophil counts in blood or bronchiolar lavage fluid or in FeNO level, and there was a negative correlation between peripheral blood eosinophil counts and changes in AHR; these findings suggest a mechanism targeting both T2 and non-T2 pathways in mast cells. 50 Mast cells serve as a source of T2 cytokines 51 and a shift in mast cells to the airway https://doi.org/10.2147/JAA.S410592…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…50 Reductions in AHR with imatinib were noted without an associated effect on eosinophil counts in blood or bronchiolar lavage fluid or in FeNO level, and there was a negative correlation between peripheral blood eosinophil counts and changes in AHR; these findings suggest a mechanism targeting both T2 and non-T2 pathways in mast cells. 50 Mast cells serve as a source of T2 cytokines 51 and a shift in mast cells to the airway https://doi.org/10.2147/JAA.S410592…”
Section: Discussionmentioning
confidence: 99%
“… 50 Reductions in AHR with imatinib were noted without an associated effect on eosinophil counts in blood or bronchiolar lavage fluid or in FeNO level, and there was a negative correlation between peripheral blood eosinophil counts and changes in AHR; these findings suggest a mechanism targeting both T2 and non-T2 pathways in mast cells. 50 Mast cells serve as a source of T2 cytokines 51 and a shift in mast cells to the airway epithelium has been associated with both T2 gene expression in the airways and indirect AHR in the form of exercise-induced bronchoconstriction (EIB), a form of AHR that correlates with mannitol induced AHR. 11 However, non-T2 mast cell-derived products are also implicated in AHR as some patients with EIB do not have high T2 gene expression.…”
Section: Discussionmentioning
confidence: 99%