Identification of MicroRNAs controlling human ovarian cell proliferation and apoptosis

Sirotkin, Alexander V.; Lauková, Marcela; Ovcharenko, Dmitriy; Brenaut, Pauline; Mlyncek, M

doi:10.1002/jcp.21999

Cited by 187 publications

(140 citation statements)

References 31 publications

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“…Whether, physiologically, miR-224, miR-383 and miR-378 are each involved in regulation of aromatase during different stages of follicle development has not been determined. In addition, large-scale functional testing in human granulosa cells revealed effects of multiple miRNAs on the production of progesterone, testosterone and oestradiol, as well as in the expression of the markers of proliferation and apoptosis, PCNA and BAX, although no attempt was made to investigate the mechanisms involved in these responses (Sirotkin et al 2009(Sirotkin et al , 2010.…”

Section: Involvement Of Mirnas During Follicular Growth and Steroidogmentioning

confidence: 99%

Involvement of miRNAs in ovarian follicular and luteal development

Donadeu¹,

Schauer²,

Sontakke³

2012

Journal of Endocrinology

164

110

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Although much progress has been made in the genetic dissection of biological networks involved in follicular/luteal development in the mammalian ovary, the gene regulation mechanisms involved are still poorly understood. Over the last 10 years, miRNAs have emerged as master regulators of tissue growth and differentiation in animals. However, compared with other body tissues, little is still known about the functional involvement of miRNAs in the ovary. Several studies have identified miRNA populations specifically associated with the development of follicles and corpora lutea, particularly in relation to the follicular-luteal transition, and the functional involvement of some of these miRNAs has been characterised in vitro and/or in vivo. Specifically, three different miRNAs, miR-224, miR-378 and miR-383, have shown to be involved in regulating aromatase expression during follicle development. In addition, miR-21 has been identified as promoting follicular cell survival during ovulation, and pro-angiogenic miR-17-5p and let-7b were shown to be necessary for normal development of the corpus luteum. Experimental evidence for the involvement of several other miRNAs in different aspects of follicle/luteal development has also been obtained. In addition, many of these studies exemplify the challenges associated with identifying physiologically relevant targets of ovarian miRNAs. Continuous advances in this field will be considerably facilitated by progress in understanding miRNA physiology in other body systems and will eventually lead to a much better understanding of the control of follicular/luteal development. In turn, through the potential offered by miRNA diagnostics and miRNA therapeutics, this new knowledge should bring considerable benefits to reproductive medicine.

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Section: Involvement Of Mirnas During Follicular Growth and Steroidogmentioning

confidence: 99%

Involvement of miRNAs in ovarian follicular and luteal development

Donadeu¹,

Schauer²,

Sontakke³

2012

Journal of Endocrinology

164

110

View full text Add to dashboard Cite

show abstract

“…Increasing evidences on the role of miRNAs during female reproduction point to an association between these molecules and several diseases, which generally affect oocyte developmental competence (Sirotkin et al, 2010;Roth et al, 2014) at least in humans. Although data in domestic animals are not available yet, it is of interest to consider this aspect as well, since it may have a wider impact than currently perceived.…”

Section: Alteration Of Mirna Expression and Implications For Female Fmentioning

confidence: 99%

In search of the transcriptional blueprints of a competent oocyte

et al. 2017

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The oocyte undergoes a remarkably long and elaborated journey within the follicle before becoming fully equipped to sustain embryonic development. Its ability to support early embryonic development relies largely on the maternal transcripts accumulated during its growth and maturation. However, it is still not clear what transcriptome blueprint composes a competent oocyte. A number of extensive studies provided a detailed characterization of the mRNA molecules that are gradually accumulated in the oocyte cytoplasm. The detail of our knowledge has gradually increased through the years also thanks to the development and improvement of the analytical techniques. From realtime PCR analysis of single transcripts, to the whole transcriptome approach of gene arrays and new genereation sequencing, scientists accumulated an exponentially growing amount of new information. More recently, the discovery of non-coding RNAs revealed a new layer of complexity in the mechanisms that modulate gene expression at the mRNA level, in folliculogenesis and oogenesis. In particular, data are emerging on the potential role of microRNAs in controlling ovarian function, oocyte maturation and the oocyte-somatic cell cross talk. This review will try to summarize the vast amount of data currently available on the mRNAs and microRNAs associated with the ovarian function and to find their biological significance.

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“…Several studies have indicated the involvement of miRNAs in regulating the proliferation, differentiation, survival, cell cycle transition and/or apoptosis of granulosa cells (Carletti et al, 2010;Sirotkin et al, 2010;Yin et al, 2014;Andreas et al, 2016;Gebremedhn et al, 2016). Interestingly, in vitro granulosa cell culture models have become most popular and widely used to understand the potential role of miRNAs in ovarian functions.…”

Section: Potential Role Of Mirnas In Controlling Ovarian Functionsmentioning

confidence: 99%

Dynamics and role of MicroRNAs during mammalian follicular development

Gebremedhn¹,

Pandey²,

Salilew‐Wondim³

et al. 2016

Anim Reprod

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Ovarian functions, which involve dynamically regulated processes of selection, recruitment and dominance, are known to be regulated by an array of genes, which are expressed in spatiotemporal manner in follicular somatic cells and gametes. This differential expression of genes in mammalian follicular cells is partly regulated by posttranscriptional gene regulators named microRNAs (miRNAs). In addition to the cellular miRNAs, growing number of evidences are available on the potential role of extracellular vesicles mediated transfer of miRNAs in follicular fluid. These extracellular vesicles are shown to be involved in cellto-cell communication within the follicular environment. The molecular messages carried by the extracellular vesicles released into extracellular space are thought to be reflections of the physiological status of the cells from where they are released. Therefore due to their structural nature and potential to cargo several physiologically relevant molecules, exosomes have a great potential to be used as markers of oocyte developmental competence in follicular environment. Here, we review large sets of literatures to show the dynamic nature of miRNAs during various stages of mammalian follicular development, oocyte growth and the role of some of the miRNAs in ovarian cell functions. Moreover, the presence of microvesicle and exosome-coupled extracellular miRNAs in mammalian follicular fluid and their potential involvement in cellto-cell communication are briefly discussed.

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Identification of MicroRNAs controlling human ovarian cell proliferation and apoptosis

Cited by 187 publications

References 31 publications

Involvement of miRNAs in ovarian follicular and luteal development

Involvement of miRNAs in ovarian follicular and luteal development

In search of the transcriptional blueprints of a competent oocyte

Dynamics and role of MicroRNAs during mammalian follicular development

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