Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells

Sumiyoshi, Kumi; Kubota, Satoshi; Ohgawara, Toshihiro; Kawata, Kazumi; Nishida, Takashi; Shimo, Tsuyoshi; Yamashiro, Takashi; Takigawa, Masaharu

doi:10.1016/j.bbrc.2010.10.016

Cited by 34 publications

(26 citation statements)

References 22 publications

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“…Muscle microRNAs in development and disease Mitchelson KR et al . Muscle microRNAs in development and disease (latestage) differentiation of chondrocytes in growth cartilage [78] . This differentiation could be reversed by transfection and overexpression of miR1 which repressed the expression of aggrecan, the major cartilaginous proteoglycan gene in human chondrocytic HCS-2/8 cells and normal chicken chondrocytes.…”

Section: Klf15mentioning

confidence: 99%

Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Mitchelson¹

2015

WJBC

140

132

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MicroRNAs are small non-coding RNAs that participate in different biological processes, providing subtle combinational regulation of cellular pathways, often by regulating components of signalling pathways. Aberrant expression of miRNAs is an important factor in the development and progression of disease. The canonical myomiRs (miR-1, -133 and -206) are central to the development and health of mammalian skeletal and cardiac muscles, but new findings show they have regulatory roles in the development of other mammalian non-muscle tissues, including nerve, brain structures, adipose and some specialised immunological cells. Moreover, the deregulation of myomiR expression is associated with a variety of different cancers, where typically they have tumor suppressor functions, although examples of an oncogenic role illustrate their diverse function in different cell environments. This review examines the involvement of the related myomiRs at the crossroads between cell development/ tissue regeneration/tissue inflammation responses, and cancer development. Core tip: The roles of the canonical muscle-associated microRNAs are reviewed, including microRNA families miR-1 and miR-133, and single miR-206, which are collectively known as the "myomiRs". The myomiRs act at the crossroads of the molecular regulation of muscle cells, linking between pathways for cell differentiation, development and maintenance, but also potentiate aberrant cell growth in numerous non-muscle cancers. Typically myomiRs are downregulated in cancers, but some myomiRs are upregulated in a few cancers, yet each dysregulation event advances tumor progression. The review examines normal and disease-linked molecular changes associated with the myomiRs, and collates the extensive literature into accessible tables. REVIEW

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Section: Klf15mentioning

confidence: 99%

Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Mitchelson¹

2015

WJBC

140

132

View full text Add to dashboard Cite

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“…Sumiyoshi et al found that miR-1 was repressed upon hypertrophic differentiation of chondrocytes [45]. MiR-1 overexpression in a human chondrocytic cell line (HCS-2/8) and chicken primary chondrocytes reduced aggrecan expression, demonstrating the inhibitory role of miR-1 in chondrogenesis.…”

Section: The Role Of Mirnas In Chondrocytesmentioning

confidence: 99%

MicroRNAs involved in bone formation

Papaioannou

Mirzamohammadi

Kobayashi

2014

Cell. Mol. Life Sci.

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During skeletal development, mesenchymal progenitor cells undergo a multistage differentiation process in which they proliferate and become bone- and cartilage-forming cells. This process is tightly regulated by multiple levels of regulatory systems. The small non-coding RNAs, microRNAs (miRNAs), post-transcriptionally regulate gene expression. Recent studies have demonstrated that miRNAs play significant roles in all stages of bone formation, suggesting the possibility that miRNAs can be novel therapeutic targets for skeletal diseases. Here, we review the role and mechanism of action of miRNAs in bone formation. We discuss roles of specific miRNAs in major types of bone cells, osteoblasts, chondrocytes, osteoclasts, and their progenitors. Except a few, the current knowledge about miRNAs in bone formation has been obtained mainly by in vitro studies; further validation of these findings in vivo is awaited. We also discuss about several miRNAs of particular interest in the light of future therapies of bone diseases.

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“…miR-1 was found to be downregulated upon hypertrophic differentiation of chondrocytes [25]. miR-1 overexpression in HCS-2/8 cells and chicken primary chondrocytes reduced aggrecan expression.…”

Section: Role Of Mirnas In Cartilage Developmentmentioning

confidence: 99%

microRNAs in Cartilage Development, Homeostasis, and Disease

Mirzamohammadi

Papaioannou

Kobayashi

2014

Curr Osteoporos Rep

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microRNAs (miRNAs) regulate gene expression mainly at the posttranscriptional level. Many different miRNAs are expressed in chondrocytes, and each individual miRNA can regulate hundreds of target genes, creating a complex gene regulatory network. Experimental evidence suggests that miRNAs play significant roles in various aspects of cartilage development, homeostasis, and pathology. The possibility that miRNAs can be novel therapeutic targets for cartilage diseases led to vigorous investigations to understand the role of individual miRNAs in skeletal tissues. Here, we summarize our current understanding of miRNAs in chondrocytes and cartilage. In the first part, we discuss roles of miRNAs in growth plate development and chondrocyte differentiation. In the second part, we put a particular focus on articular cartilage and discuss the significance of variety of findings in the context of osteoarthritis, the most common degenerative joint disease.

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Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells

Cited by 34 publications

References 22 publications

Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

MicroRNAs involved in bone formation

microRNAs in Cartilage Development, Homeostasis, and Disease

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