Identification of miR-22-3p, miR-92a-3p, and miR-137 in peripheral blood as biomarker for schizophrenia

Ma, Jie; Shang, Shan-shan; Wang, Jihan; Zhang, Tianbu; Nie, Fayi; Song, Xiaobin; Zhao, Heping; C, Zhu; Zhang, Rui; Hao, Dingjun

doi:10.1016/j.psychres.2018.03.080

Cited by 66 publications

(46 citation statements)

References 42 publications

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“…Upregulation of circulating miR-92a-3p was observed in the plasma of both mild cognitive impairment and Alzheimer disease subjects [90] and was proposed as a biomarker of schizophrenia [91]. In our study, downregulated miR-92a-3p putatively targets upregulated PRRC2B (Figure 4), which is a gene encoding protein involved in brain development [92].…”

Section: Discussionmentioning

confidence: 52%

Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease

Zalewski

Ruszel

Stępniewski

et al. 2020

JCM

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Chronic venous disease (CVD) is a vascular disease of lower limbs with high prevalence worldwide. Pathologic features include varicose veins, venous valves dysfunction and skin ulceration resulting from dysfunction of cell proliferation, apoptosis and angiogenesis. These processes are partly regulated by microRNA (miRNA)-dependent modulation of gene expression, pointing to miRNA as a potentially important target in diagnosis and therapy of CVD progression. The aim of the study was to analyze alterations of miRNA and gene expression in CVD, as well as to identify miRNA-mediated changes in gene expression and their potential link to CVD development. Using next generation sequencing, miRNA and gene expression profiles in peripheral blood mononuclear cells of subjects with CVD in relation to healthy controls were studied. Thirty-one miRNAs and 62 genes were recognized as potential biomarkers of CVD using DESeq2, Uninformative Variable Elimination by Partial Least Squares (UVE-PLS) and ROC (Receiver Operating Characteristics) methods. Regulatory interactions between potential biomarker miRNAs and genes were projected. Functional analysis of microRNA-regulated genes revealed terms closely related to cardiovascular diseases and risk factors. The study shed new light on miRNA-dependent regulatory mechanisms involved in the pathology of CVD. MicroRNAs and genes proposed as CVD biomarkers may be used to develop new diagnostic and therapeutic methods.

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Section: Discussionmentioning

confidence: 52%

Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease

Zalewski

Ruszel

Stępniewski

et al. 2020

JCM

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“…The up-regulation of miR-137 in peripheral tissues in schizophrenia was also reported in three independent studies, suggesting it may have applications as a biomarker [86,91,157]. miR-137, first identified in the mouse midbrain cortical tissue [158], is a brain-enriched miRNA predicted to target over 1000 genes involved in various pathways, such as cell cycle, neural development, proliferation, and differentiation.…”

Section: Discussion and Perspectivesmentioning

confidence: 64%

“…Recently, a combination of miR-22-3p, miR-92a-3p, and miR-137 was suggested as a schizophrenia diagnosis biomarker following an investigation on peripheral blood from ten patients and ten healthy controls [91]. Yu and collaborators applied microarray and qRT-PCR to investigate for disease biomarkers in the PBMCs of 105 schizophrenia patients compared to 130 psychiatrically healthy people and observed a decreased expression of miR-132 [95].…”

Section: Mirnamentioning

confidence: 99%

Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers

Khavari

Cairns

2020

Cells

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Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very significant range of environmental exposures and stressors that have been implicated in disease development and neuropathology, such as maternal immune infection, obstetric complications, childhood trauma and cannabis exposure. It is postulated that epigenetic factors, as well as regulatory non-coding RNAs, mediate the effects of these environmental stressors. In this review, we explore the most well-known epigenetic marks, including DNA methylation and histone modification, along with emerging RNA mediators of epigenomic state, including miRNAs and lncRNAs, and discuss their collective potential for involvement in the pathophysiology of schizophrenia implicated through the postmortem analysis of brain tissue. Given that peripheral tissues, such as blood, saliva, and olfactory epithelium have the same genetic composition and are exposed to many of the same environmental exposures, we also examine some studies supporting the application of peripheral tissues for epigenomic biomarker discovery in schizophrenia. Finally, we provide some perspective on how these biomarkers may be utilized to capture a signature of past events that informs future treatment.

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“…The available information in the literature on these miRNA variants is rather scarce. Interestingly, mir-92a has been already linked to bipolar disorder (32) and proposed as possible biomarker for schizophrenia (33), while mir-491 has been linked to panic disorders (34) and major depression (35). Moreover, mir-447 has been recently detected in the blood of ADHD patients (36), one of the shared comorbidities of TS.…”

Section: Discussionmentioning

confidence: 99%

Association of Genetic Variation in the 3'UTR of LHX6, IMMP2L, and AADAC With Tourette Syndrome

et al. 2020

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Background: Tourette Syndrome (TS) is a neurodevelopmental disorder that presents with motor and vocal tics early in childhood. The aim of this study was to investigate genetic variants in the 3' untranslated region (3'UTR) of TS candidate genes with a putative link to microRNA (miRNA) mediated regulation or gene expression. Methods: We used an in silico approach to identify 32 variants in the 3'UTR of 18 candidate genes putatively changing the binding site for miRNAs. In a sample composed of TS cases and controls (n = 290), as well as TS family trios (n = 148), we performed transmission disequilibrium test (TDT) and meta-analysis. Results: We found positive association of rs3750486 in the LIM homeobox 6 (LHX6) gene (p = 0.021) and rs7795011 in the inner mitochondrial membrane peptidase subunit 2 (IMMP2L) gene (p = 0.029) with TS in our meta-analysis. The TDT showed an over-transmission of the A allele of rs1042201 in the arylacetamide deacetylase (AADAC) gene in TS patients (p = 0.029). Conclusion: This preliminary study provides further support for the involvement of LHX6, IMMP2L, and AADAC genes, as well as epigenetic mechanisms, such as altered miRNA mediated gene expression regulation in the etiology of TS.

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Identification of miR-22-3p, miR-92a-3p, and miR-137 in peripheral blood as biomarker for schizophrenia

Cited by 66 publications

References 42 publications

Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease

Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease

Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers

Association of Genetic Variation in the 3'UTR of LHX6, IMMP2L, and AADAC With Tourette Syndrome

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