Identification of mitochondrial hormone receptors in avian muscle cells

Lassiter, Kentu; Dridi, Sami; Greene, Elisabeth; Kong, Byung-Whi; Bottje, Walter

doi:10.3382/ps/pey126

Cited by 10 publications

(8 citation statements)

References 38 publications

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“…Mitochondria are the powerhouse of cells, converting nutrients into ATP to sustain cellular functions 24 . Mitochondrial density and bioenergetics are likely to be influenced by THs across taxa ( 25 , 26 , reviewed in 27 ) and by ambient temperature 28 . However, to our knowledge, the effects of prenatal THs on mitochondria have not been characterized beyond mammalian models 29 .…”

Section: Introductionmentioning

confidence: 99%

Testing for context-dependent effects of prenatal thyroid hormones on offspring survival and physiology: an experimental temperature manipulation

Hsu

Sarraude

Cossin-Sevrin

et al. 2020

Sci Rep

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Maternal effects via hormonal transfer from the mother to the offspring provide a tool to translate environmental cues to the offspring. Experimental manipulations of maternally transferred hormones have yielded increasingly contradictory results, which may be explained by differential effects of hormones under different environmental contexts. Yet context-dependent effects have rarely been experimentally tested. We therefore studied whether maternally transferred thyroid hormones (THs) exert context-dependent effects on offspring survival and physiology by manipulating both egg TH levels and post-hatching nest temperature in wild pied flycatchers ( Ficedula hypoleuca ) using a full factorial design. We found no clear evidence for context-dependent effects of prenatal THs related to postnatal temperature on growth, survival and potential underlying physiological responses (plasma TH levels, oxidative stress and mitochondrial density). We conclude that future studies should test for other key environmental conditions, such as food availability, to understand potential context-dependent effects of maternally transmitted hormones on offspring, and their role in adapting to changing environments.

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Section: Introductionmentioning

confidence: 99%

Testing for context-dependent effects of prenatal thyroid hormones on offspring survival and physiology: an experimental temperature manipulation

Hsu

Sarraude

Cossin-Sevrin

et al. 2020

Sci Rep

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“…They are likely involved in regulating nonshivering thermogenesis (NST), while shivering thermogenesis (ST) may be predominantly controlled directly via neuronal mechanisms (Morrison et al, 2008). Mitochondria in avian skeletal muscle have recently been found to express thyroid hormone receptors (see e.g.Cioffi et al, 2013 for reviews on mammals; Lanni et al, 2016;Lassiter et al, 2018). For example, an increase in potential uncoupling protein, avUCP, expression was associated with increased plasma T3 levels and heat production in chicken (Collin et al, 2003a).…”

Section: Endocrine and Molecular Mechanisms Of Thermoregulation In Birdsmentioning

confidence: 99%

Endocrinology of thermoregulation in birds in a changing climate

Ruuskanen¹,

Hsu²,

Nord³

2019

Preprint

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The ability to maintain a (relatively) stable body temperature in a wide range of thermal environments is a unique feature of endotherms such as birds. Endothermy is acquired and regulated via various endocrine and molecular pathways, and ultimately allows wide aerial, aquatic, and terrestrial distribution in variable environments. However, due to our changing climate, birds are faced with potential new challenges for thermoregulation, such as more frequent extreme weather events, lower predictability of climate, and increasing mean temperature. We provide a compact overview on thermoregulation in birds and its endocrine and molecular mechanisms, pinpointing gaps in current knowledge and recent developments, focusing especially on non-model species to understand the generality of, and variation in, mechanisms. We highlight plasticity in thermoregulation and underlying endocrine regulation, because thorough understanding of plasticity is key to predicting responses to changing environmental conditions. To this end, we discuss how changing climate is likely to affect avian thermoregulation and associated endocrine traits, and how the interplay between these physiological processes may play a role in facilitating or constraining adaptation to a changing climate. We conclude that while the general patterns of endocrine regulation of thermogenesis are quite well understood, at least in poultry, the molecular and endocrine mechanisms that regulate e.g. mitochondria function and plasticity of thermoregulation over different time scales (from transgenerational to daily variation) need to be unveiled. Plasticity may ameliorate climate change effects on thermoregulation to some extent, but the increased frequency of extreme weather events, and associated in resource availability, may be beyond the scope and/or speed for plastic responses. This could lead to selection for more tolerant phenotypes, if the underlying physiological traits harbour genetic and individual variation for selection to act on – a key question for future research.

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“…It is therefore possible that the programming of mitochondrial function that we have demonstrated in this more comprehensively treated group, may result from parental effects that were transmitted from the parents through egg provisioning (Lanni et al 2016;Lassiter et al 2018).…”

Section: Discussionmentioning

confidence: 98%

Short and long-term consequences of heat exposure on mitochondrial metabolism in zebra finches (Taeniopygia guttata)

Pacheco-Fuentes

Ton

Griffith

2022

Preprint

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Understanding the consequences of heat exposure on mitochondrial function is crucial as mitochondria lie at the core of metabolic processes, also affecting population dynamics. In adults, mitochondrial metabolism varies with temperature but can also depend on thermal conditions experienced during development. We exposed zebra finches to two alternative heat-treatments during early development; “constant”, maintained birds at ambient 35°C from parental pair formation to fledglings’ independence, while “periodic” heated broods at 40°C, six hours daily at nestling stage. Two years later, we acclimated birds from both experiments at 25°C for 21 days, before exposing them to artificial heat (40°C, five hours daily for ten days). After both conditions we measured red blood cells’ mitochondrial metabolism using a high-resolution respirometer. We found significantly decreased mitochondrial metabolism for Routine, Oxidative Phosphorylation (OxPhos) and Electron Transport System maximum capacity (ETS) after the heat-treatments. Additionally, the birds exposed to “constant” heat in early life showed lower oxygen consumption at the proton leak (Leak) stage after the heat treatment as adults. Females showed higher mitochondrial respiration for Routine, ETS and Leak independently of treatments, while this pattern was reversed for OxPhos coupling efficiency (OxCE). Our results show that short-term acclimation involved reduced mitochondrial respiration, and that the reaction of adult birds to heat depends on the intensity, pattern and duration of temperature conditions experienced at early-life stages. Our study provides insight into the complexity underlying variation in mitochondrial metabolism and raises questions on the adaptive value of long-lasting physiological adjustments triggered by the early-life thermal environment.

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Identification of mitochondrial hormone receptors in avian muscle cells

Cited by 10 publications

References 38 publications

Testing for context-dependent effects of prenatal thyroid hormones on offspring survival and physiology: an experimental temperature manipulation

Testing for context-dependent effects of prenatal thyroid hormones on offspring survival and physiology: an experimental temperature manipulation

Endocrinology of thermoregulation in birds in a changing climate

Short and long-term consequences of heat exposure on mitochondrial metabolism in zebra finches (Taeniopygia guttata)

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