2024
DOI: 10.2147/idr.s457308
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Identification of Mycobacterium tuberculosis Resistance to Common Antibiotics: An Overview of Current Methods and Techniques

Xue-Song Xiong,
Xue-Di Zhang,
Jia-Wei Yan
et al.

Abstract: Multidrug-resistant tuberculosis (MDR-TB) is an essential cause of tuberculosis treatment failure and death of tuberculosis patients. The rapid and reliable profiling of Mycobacterium tuberculosis (MTB) drug resistance in the early stage is a critical research area for public health. Then, most traditional approaches for detecting MTB are time-consuming and costly, leading to the inappropriate therapeutic schedule resting on the ambiguous information of MTB drug resistance, increasing pa… Show more

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Cited by 5 publications
(1 citation statement)
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“…First-line anti-tuberculosis drugs, such as isoniazid, rifampicin, and pyrazinamide, are essential components of standard TB treatment regimens and play a crucial role in controlling Mtb growth and spread [ 170 ]. Unfortunately, standard antibiotic therapy involves expensive long-term treatment and side effects and has led to the development of multi-drug-resistant TB [ 171 ]. Alternative antibiotics and nitroimidazoles, such as delamanid and pretomanid, have been investigated; however, concerns exist over their resistance and side effects [ 172 ].…”
Section: Therapeutic Considerations Targeting Autophagy Apoptosis And...mentioning
confidence: 99%
“…First-line anti-tuberculosis drugs, such as isoniazid, rifampicin, and pyrazinamide, are essential components of standard TB treatment regimens and play a crucial role in controlling Mtb growth and spread [ 170 ]. Unfortunately, standard antibiotic therapy involves expensive long-term treatment and side effects and has led to the development of multi-drug-resistant TB [ 171 ]. Alternative antibiotics and nitroimidazoles, such as delamanid and pretomanid, have been investigated; however, concerns exist over their resistance and side effects [ 172 ].…”
Section: Therapeutic Considerations Targeting Autophagy Apoptosis And...mentioning
confidence: 99%