2019
DOI: 10.3390/jof5040090
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Identification of Mycoses in Developing Countries

Abstract: Extensive advances in technology offer a vast variety of diagnostic methods that save time and costs, but identification of fungal species causing human infections remains challenging in developing countries. Since the echinocandins, antifungals widely used to treat invasive mycoses, are still unavailable in developing countries where a considerable number of problematic fungal species are present, rapid and reliable identification is of paramount importance. Unaffordability, large footprints, lack of skilled … Show more

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Cited by 51 publications
(43 citation statements)
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References 159 publications
(202 reference statements)
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“…As some isolates were clonal and/or belonged to the same genotype, horizontal transfer could be suggested; however, this hypothesis requires experimental confirmation by performing whole genome sequencing and environmental screening, which are beyond the scope of our study. Nowadays, various next‐generation sequencing platforms have been increasingly employed to assess genotypic diversity as well as to identify mutations responsible for antifungal resistance, which may not be used for a particular gene but rather for numerous genes scattered throughout the genome 59‐61 . In contrast to a previous study, 28 in our study we did not observe the phenomenon of clonal enrichment for FLZ‐resistant C glabrata isolates as evidenced by the lack of statistical association between FLZ MIC values and cluster and MMT patterns (Figure 2).…”
Section: Resultscontrasting
confidence: 96%
“…As some isolates were clonal and/or belonged to the same genotype, horizontal transfer could be suggested; however, this hypothesis requires experimental confirmation by performing whole genome sequencing and environmental screening, which are beyond the scope of our study. Nowadays, various next‐generation sequencing platforms have been increasingly employed to assess genotypic diversity as well as to identify mutations responsible for antifungal resistance, which may not be used for a particular gene but rather for numerous genes scattered throughout the genome 59‐61 . In contrast to a previous study, 28 in our study we did not observe the phenomenon of clonal enrichment for FLZ‐resistant C glabrata isolates as evidenced by the lack of statistical association between FLZ MIC values and cluster and MMT patterns (Figure 2).…”
Section: Resultscontrasting
confidence: 96%
“…None of those studies have used specific definitions and standardized diagnostic algorithms to identify and define CAPA. In fact, diagnosis of pulmonary aspergillosis is challenging with culture exhibiting limited sensitivity [73,74], and galactomannan testing-the current gold standard-is rarely available in China [75]. As a result, some of these reported rates are likely an underestimate of the real burden of IPA in patients with COVID-19 requiring ICU admission, while other rates may be an overestimation due to potentially misinterpreting Aspergillus colonization in the upper respiratory tract as Aspergillus infection.…”
Section: Capa Prevalencementioning
confidence: 99%
“…This can activate the β‐lactamase to cleave its substrate nitrocefin, producing a colored product suggesting that the C. albicans DNA is present (Figure 11A). In addition, Arastehfar et al forecasted that SHERLOCKv2 supplemented with an efficient DNA extraction tool holds promise as a portable platform to detect pathogenic fungal species, which also indicates that CRISPR‐Cas system has potential for fungal diagnosis 74 …”
Section: Crispr/cas–based In Vitro Diagnosticsmentioning
confidence: 99%