Identification of neuromuscular targets for restoration of walking ability after stroke: Precursor to precision rehabilitation

Abstract

Objectives Restoration of walking is a priority for stroke survivors and key target for physical therapies. Upright pedalling (UP) can provide functional walking‐like activity using a variety of muscle synergies; it is unclear which synergies might be most useful for recovery of walking. Objectives here were as follows: to examine whether neuromuscular measures derived during UP might identify targets for walking rehabilitation after stroke and to determine test–retest repeatability and concurrent validity of the measures. Design This was a prospective correlational study. Setting The study was carried out in a movement science laboratory. Participants The participants were 18 adults with stroke (StrS) and 10 healthy older adults (HOA). Intervention/measurement StrS and HOA took part in two identical measurement sessions. During UP, surface electromyography and kinematic data were recorded and then processed to derive three measures: reciprocal activity of quadriceps and hamstrings; percentage muscle activity “on” according to crank angle; and smoothness of movement. Results HOA and StrS demonstrated differences in reciprocal muscle activity (p = .044) and quadriceps activity according to crank angle (p = .034) but pedalled similarly smoothly (p = .367). For muscle activation according to crank angle in StrS, intraclass correlation coefficients (95% confidence interval) showing acceptable repeatability were 0.46 [0.32, 0.58] affected quadriceps; 0.43 [0.28, 0.56] affected hamstrings; and 0.67 [0.56, 0.75] unaffected quadriceps. Conclusion Muscle activation according to crank angle is a promising measure of lower limb impairment during functional activity after stroke; subsequent investigation should determine magnitude of variance between testing sessions. Reciprocal activity of quadriceps and hamstrings muscles and quadriceps activity according to crank angle are both potential targets for physical therapies to improve motor recovery. Further investigations are warranted.

Investigating the Relationships Between Three Important Functional Tasks Early After Stroke: Movement Characteristics of Sit-To-Stand, Sit-To-Walk, and Walking

“…An understanding of such characteristics is crucial to understanding neuromuscular restitution (11). Sensitive, objective measurement of movement patterns is key to this understanding and can be achieved using kinetics and kinematics during functional activity (11,12), yet, other measures predominate; walking speed is a current foremost measure of functional ability (13). This may not be the appropriate measure to investigate neuromuscular restitution, as observation indicates that people using compensatory movement patterns-"neuromuscular substitution"-can walk at the same speed as people who do not (13).…”