Identification of new genes of pleomorphic adenoma

Choi, Jeong‐Seok; Cho, Byung Han; Kim, Hong-Ju; Kim, Young-Mo; Jang, Jun‐Hyeog

doi:10.1097/md.0000000000018468

Cited by 18 publications

(13 citation statements)

References 22 publications

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“…The results of the Kaplan-Meier plotter analysis determined that the high expression groups of CD44, CCND3, NCALD and MACF1 had an improved prognosis compared with the low expression groups, while KCTD15 exhibited the opposite trend. To the best of our knowledge, KCTD15 upregulation has never been reported to be associated with pathological states, although it has been indirectly associated with several types of cancer, such as pleomorphic adenoma and medulloblastoma (39,40). The specific role of KCTD15 in LUAD should be investigated in future studies.…”

Section: Discussionmentioning

confidence: 95%

Identification of key genes in lung adenocarcinoma based on a competing endogenous RNA network

Song

Zhang

Chen³

et al. 2020

Oncol Lett

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Lung adenocarcinoma (LUAD) is the most commonly diagnosed type of lung cancer and exhibits a high morbidity. The present study aimed to investigate the long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) mechanisms in LUAD. The receptor activity modifying protein 2-antisense RNA 1 (RAMP2-AS1) was identified using GSE113852 and GSE130779 datasets downloaded from the Gene Expression Omnibus database, and the downregulation of RAMP2-AS1 was the most significant in LUAD. In addition, microRNA (miR)-296-5p was identified to bind to RAMP2-AS1 via bioinformatics analysis. Subsequently, CD44, cyclin D3 (CCND3), neurocalcin δ (NCALD), microtubule actin crosslinking factor 1 (MACF1) and potassium channel tetramerization domain containing 15 were obtained by intersecting the predicted target genes of miR-296-5p and 368 differentially expressed mRNAs in LUAD. According to the Gene Expression Profiling Interactive Analysis and UALCAN databases, these five mRNAs were downregulated in LUAD, and their expression levels were positively correlated with those of RAMP2-AS1. CD44, CCND3, NCALD and MACF1 were selected as key mRNAs in LUAD based on prognostic analyses. Furthermore, functional enrichment analyses were performed and an interaction network was constructed to reveal the functions of the RAMP2-AS1-associated ceRNA in LUAD. The results indicated that the functions were mainly enriched in generic transcription pathways, cyclin D-associated events in G 1 and epithelial stromal transformation. Reverse transcription-quantitative PCR assays revealed that RAMP2-AS1, CD44, CCND3, NCALD and MACF1 expression was lower in tumor tissues than in normal tissues, while miR-296-5p expression was higher in tumor tissues compared with in normal tissues. The association between RAMP2-AS1 and MACF1 was further confirmed using in vitro experiments. Overall, the present results indicated that RAMP2-AS1, miR-296-5p, CD44, CCND3, NCALD and MACF1 may be involved in LUAD progression and may therefore serve as potential biomarkers and provide a theoretical basis for the study of the pathogenesis of LUAD.

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Section: Discussionmentioning

confidence: 95%

Identification of key genes in lung adenocarcinoma based on a competing endogenous RNA network

Song

Zhang

Chen³

et al. 2020

Oncol Lett

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“…The PA Gene 1, PLAG1, is reportedly activated by chromosome rearrangements in both pleomorphic adenoma and myoepithelioma [13,14]. Using a variety of cytogenetic, molecular cytogenetic and molecular karyotyping based techniques, Thielker et al [15] recently reported chromosomal and/or submicroscopic alterations in 5 of 14 cases of PA, e.g., jumping translocation, gene copy variations involving twist-replated protein 1 (TWIST1) and distal-less homeobox 5 (DLX5) genes [15] ) could be potential biomarkers for a precise diagnosis of PA [16]. Lastly, Mariano et al [17] report that PA exhibited only a few copy alterations with the most frequent involving chromosomes 8:8p21.3-p12 (gain), 8q12.1 (loss), 8p23.3-q24.3 (gain), and 8q12.1-q21.11 (gain).…”

Section: Clinical Presentation and Etiologymentioning

confidence: 99%

Pleomorphic Adenoma with A Prominent Myoepithelial Cell Component: Case Report with Abbreviated Review of Literature

Ne¹,

Jl²,

Cm³

2021

COS

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Pleomorphic adenoma, also known as a mixed tumor, is the most common benign tumor involving salivary glands with the parotid and minor palatal glands being common sites of occurrence. Histologically, pleomorphic adenoma can exhibit a wide variation in epithelial and stromal components, such as myxoid, chondroid, osteoid, and clear, spindle-shaped, epitheliod or plasmacytoid myoepithelial cells. In this paper we present a brief focused review of the literature and a case report of a pleomorphic adenoma that involved both the hard and soft palates and featured a prominent plasmacytoid myoepithelial cell component.

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“…However, it is known that in more than 70% of the cases there is an association with abnormal karyotypes, involving a locus of the PLAG1 gene (Pleomorphic adenoma gene 1). Recently, new genes that may be involved in tumor formation have been identified 16 . In addition, there is evidence that exposure to UV (ultraviolet) rays increases the risk of developing it 3 .…”

Section: Introductionmentioning

confidence: 99%

Conservative Surgical Approach to Pleomorphic Adenoma in Parotid Gland: Case Report

et al. 2021

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Pleomorphic adenoma is a benign neoplasm of the salivary glands that affects most frequently females in the fourth and sixth decade of life. As it is usually an asymptomatic lesion, it is diagnosed upon routine physical examination. Treatment consists in surgical removal with partial or total involvement of the parotid gland. Conservative enucleation is the least invasive surgical option for this type of lesion. The present work aimed to report a case of pleomorphic adenoma of the parotid gland with eight years of evolution. The tumor was treated conservatively. Patient has been followed for sixth months, and no sensory alterations, fistulae, clinical signs of recurrence, nor any other alteration have been observed so far. Due to the benign nature of the lesion, an evolution with favorable prognosis is expected. Keywords: Adenoma. Benign Neoplasia. Tumor ResumoO Adenoma pleomórfico é uma neoplasia benigna de glândulas salivares, que acomete com maior frequência pessoas do sexo feminino entre a quarta e sexta década de vida. Por se tratar de uma lesão muitas vezes assintomática, geralmente é descoberta através do exame físico de rotina. O seu tratamento consiste em remoção cirúrgica podendo envolver ou não a glândula parótida de maneira parcial ou total. A enucleação conservadora é a modalidade cirúrgica menos invasiva para este tipo de lesão. O presente trabalho tem por objetivo relatar um caso de adenoma pleomórfico em glândula parótida com oito anos de evolução. O tumor foi tratado de maneira conservadora. A paciente está sendo acompanhada há 6 meses e não foram observados até momento alterações sensoriais, fistulas, indícios clínicos de recidiva ou qualquer outra alteração. Devido ao caráter benigno da lesão, espera-se evolução com prognóstico favorável. Palavras-chave: Adenoma. Neoplasia Benigna. Tumor.

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Identification of new genes of pleomorphic adenoma

Cited by 18 publications

References 22 publications

Identification of key genes in lung adenocarcinoma based on a competing endogenous RNA network

Identification of key genes in lung adenocarcinoma based on a competing endogenous RNA network

Pleomorphic Adenoma with A Prominent Myoepithelial Cell Component: Case Report with Abbreviated Review of Literature

Conservative Surgical Approach to Pleomorphic Adenoma in Parotid Gland: Case Report

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