Identification of new HLA‐DRB1 alleles in Kazakh individuals

Kuranov, A. B.; Mukhamedyarov, Damir; Momynaliev, K. Т.

doi:10.1111/j.1399-0039.2010.01611.x

Cited by 6 publications

(2 citation statements)

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“…The novel allele designations have been officially assigned by the World Health Organization Nomenclature Committee [61] . According to investigations the following 7 novel alleles were found: DRB1*03:56, DRB1*03:57, DRB1*13:102, DRB1*13:02:04, DRB1*13:103, DRB1*11:04:06 and DRB1*14:12:02 [62] . The allelic frequency distribution of the HLA-DRB1 locus in the Kazakh population of Tarbagatay region are shown in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

Polymorphisms of HLA-DRB1, -DQA1 and -DQB1 in Inhabitants of Astana, the Capital City of Kazakhstan

et al. 2014

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BackgroundKazakhstan has been inhabited by different populations, such as the Kazakh, Kyrgyz, Uzbek and others. Here we investigate allelic and haplotypic polymorphisms of human leukocyte antigen (HLA) genes at DRB1, DQA1 and DQB1 loci in the Kazakh ethnic group, and their genetic relationship between world populations.Methodology/Principal FindingsA total of 157 unrelated Kazakh ethnic individuals from Astana were genotyped using sequence based typing (SBT-Method) for HLA-DRB1, -DQA1 and -DQB1 loci. Allele frequencies, neighbor-joining method, and multidimensional scaling analysis have been obtained for comparison with other world populations. Statistical analyses were performed using Arlequin v3.11. Applying the software PAST v. 2.17 the resulting genetic distance matrix was used for a multidimensional scaling analysis (MDS). Respectively 37, 17 and 19 alleles were observed at HLA-DRB1, -DQA1 and -DQB1 loci. The most frequent alleles were HLA-DRB1*07:01 (13.1%), HLA-DQA1*03:01 (13.1%) and HLA-DQB1*03:01 (17.6%). In the observed group of Kazakhs DRB1*07:01-DQA1*02:01-DQB1*02:01 (8.0%) was the most common three loci haplotype. DRB1*10:01-DQB1*05:01 showed the strongest linkage disequilibrium. The Kazakh population shows genetic kinship with the Kazakhs from China, Uyghurs, Mongolians, Todzhinians, Tuvinians and as well as with other Siberians and Asians.Conclusions/SignificanceThe HLA-DRB1, -DQA1and -DQB1 loci are highly polymorphic in the Kazakh population, and this population has the closest relationship with other Asian and Siberian populations.

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Section: Resultsmentioning

confidence: 99%

Polymorphisms of HLA-DRB1, -DQA1 and -DQB1 in Inhabitants of Astana, the Capital City of Kazakhstan

et al. 2014

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“…The remaining allele, B*07:121 , differs from its most similar allele by two nucleotide substitutions that cause two amino acid differences. Note that new HLA alleles, two HLA‐A ( A*23:33 and A*33:41 ), six HLA‐B ( B*07:121 , B*15:216 , B*18:55 , B*27:74 , B*37:26 , and B*55:01:07 ), and previously described seven HLA‐DRB1 alleles ( DRB1*03:56 , DRB1* 03:57 , DRB1*11:04:06 , DRB1*13:02:04 , DRB1*13:102 , DRB1*13:103 , and DRB1*14:12:02 ) (4), were detected from six healthy Kazakh individuals.…”

Section: Cells and Description Of Novel Sequencesmentioning

confidence: 76%