2015
DOI: 10.1016/j.cbi.2015.01.014
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Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds

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Cited by 17 publications
(12 citation statements)
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“…Also the issue of pharmacological properties and toxicity of food colorants has not yet been exploited, as new and possibly useful pharmacological mechanisms of the routinely used colorants have been identified, e.g. Erythrosine inhibiting hematopoietic prostaglandin D2 synthase (Mazari et al, 2015) and Brilliant Blue having antiinflammatory and antidepressant effects . Therefore, systematic studies should be performed in order to elucidate pharmacological, neurodevelopmental and other effects that various colorants or their mixtures may have.…”
Section: Resultsmentioning
confidence: 99%
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“…Also the issue of pharmacological properties and toxicity of food colorants has not yet been exploited, as new and possibly useful pharmacological mechanisms of the routinely used colorants have been identified, e.g. Erythrosine inhibiting hematopoietic prostaglandin D2 synthase (Mazari et al, 2015) and Brilliant Blue having antiinflammatory and antidepressant effects . Therefore, systematic studies should be performed in order to elucidate pharmacological, neurodevelopmental and other effects that various colorants or their mixtures may have.…”
Section: Resultsmentioning
confidence: 99%
“…This mechanism could be of interest in future development of new drugs for treatment of symptoms related to allergy and asthma (Mazari et al, 2015) while Erythrosine use in the food industry does not seem to be of major concern in Europe.…”
Section: E 127 Erythrosinum Natricum Erythrosinementioning
confidence: 99%
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“…Haematopoietic prostaglandin D2 synthase (HPGDS) is a member of the sigma-class glutathione S-transferases (GSTs) 60 . HPGDS can be utilised as a cofactor in a variety of detoxification reactions, by catalysing the conjugation of mutagens and carcinogens with glutathione during mercapturic acid synthesis 49,61 .…”
Section: Discussionmentioning
confidence: 99%
“…Future studies are needed to fully understand the role of adipocyte and SVC PGD2 levels on the regulation of food intake and energy expenditure. There are currently specific HPGDS inhibitors being developed for other indications including asthma and chronic obstructive pulmonary disease ( 79 , 80 ). Our data strongly suggests that inhibition of HPGDS may also be beneficial to maintain weight loss and prevent weight regain.…”
Section: Discussionmentioning
confidence: 99%