Identification of Newly Diagnosed Diabetes and Prediabetes Using Fasting Plasma Glucose and Urinary Glucose in a Chinese Population

Chen, Juan; Guo, Hai; Qiu, Shanhu; Li, Wei; Wang, Xiao-Hang; Cai, Min; Wang, Bei; Li, Xiaoning; Sun, Zilin

doi:10.4103/0366-6999.235884

Cited by 17 publications

(23 citation statements)

References 26 publications

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“…Based on the unreliable effectiveness of FPG, some studies attempted to introduce new strategies for diabetes and prediabetes screening. Two studies showed that FPG combined with HbA 1c could significantly improve sensitivity to ~85% . HbA 1c can be tested without the restrictions of time or overnight fasting; however, it might be impractical for mass screening in rural areas of China because of the high cost associated with HbA 1c testing.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies show that HbA 1c does not detect IGT . Some studies have explored the possibility of using urine glucose for screening diabetes and prediabetes . Owing to the availability of FPG and urine glucose, this combination might be a practical alternative; however, urine glucose is affected by kidney conditions, which means it is not an appropriate method for those with renal function impairment.…”

Section: Resultsmentioning

confidence: 99%

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Use of capillary glucose combined with other non‐laboratory examinations to screen for diabetes and prediabetes

et al. 2019

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Aim To evaluate the value and feasibility of capillary glucose assessment, combined with other non‐laboratory measures, in screening for diabetes and prediabetes in the community. Methods In this cross‐sectional study, we assessed fasting capillary glucose, fasting plasma glucose, and both capillary glucose and plasma glucose values after 2‐h oral glucose tolerance tests in a total of 3736 samples. We determined the optimal threshold of capillary glucose using receiver‐operating characteristic curve analysis. The effect of screening methods using capillary glucose combined with other variables, such as age, BMI and waist circumference, was assessed according to area under the receiver‐operating characteristic curve. Results There was a strong positive correlation between capillary glucose and venous plasma glucose. The area under the curve for the model using fasting capillary glucose to screen for impaired fasting glucose was 0.722, while that for the model using capillary glucose after a 2‐h oral glucose tolerance test to screen for impaired glucose tolerance was 0.916. The area under the curve for the model using fasting capillary glucose to screen for diabetes was 0.835, while that for the model using 2‐h oral glucose tolerance test capillary glucose was 0.912. The area under the curve for the model using fasting capillary glucose + 2‐h oral glucose tolerance test capillary glucose to screen for diabetes was 0.945. The discriminatory capability of models using capillary glucose was somewhat improved by adding non‐laboratory variables. Conclusions Capillary glucose could be an alternative for screening for diabetes and prediabetes, especially in low‐resource areas.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Use of capillary glucose combined with other non‐laboratory examinations to screen for diabetes and prediabetes

et al. 2019

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“…The present study samples were derived from a cross‐sectional study performed to assess the efficacy of UGE in diabetes screening in a Chinese population with no history of diabetes . The ethical review committee of Jiangsu Provincial Centre for Disease Control and Prevention (JSJK2016‑B003‑03) approved this study, and it met the requirements of the current revision of the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

“…Blood samples were obtained for triglycerides, total cholesterol, HDL cholesterol, LDL cholesterol, creatinine and uric acid. After glucose loading, 2‐h urine samples were collected for measurement of UGE, as previously described .…”

Section: Methodsmentioning

confidence: 99%

Increased urinary glucose excretion is associated with a reduced risk of hyperuricaemia

et al. 2019

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Aim To investigate the association of urinary glucose excretion with levels of serum uric acid in adults with newly diagnosed diabetes. Methods A total of 597 people with newly diagnosed diabetes, confirmed in an oral glucose tolerance test, were included in the present study. The participants were divided into two groups: 142 participants with low urinary glucose excretion and 455 with high urinary glucose excretion. Demographic characteristics and clinical variables were evaluated. The association of urinary glucose excretion with uric acid was analysed using multivariable regression analysis. Results The low urinary glucose excretion group had a significantly higher prevalence of hyperuricaemia than the high urinary glucose excretion group. Moreover, urinary glucose excretion was negatively associated with uric acid level. The correlation remained significant after adjusting for potential confounders, including gender, age, fasting plasma glucose, 2‐h plasma glucose and BMI. The results also showed that participants with high urinary glucose excretion were at decreased risk of hyperuricaemia (odds ratio 0.47, 95% CI 0.27–0.80; P = 0.006). Conclusion Urinary glucose excretion was independently associated with uric acid level in participants with newly diagnosed diabetes. In addition to lowering blood glucose, promoting urinary glucose excretion may also be an effective approach to reducing serum uric acid levels, especially for people with diabetes complicated with hyperuricaemia.

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“…Data were obtained from a cross-sectional study undertaken to evaluate the efficacy of UGE in diabetes screening in Chinese population, aged 18–65 years and without previously diagnosed diabetes or taking anti-diabetic medication ( Chen et al, 2018b ). This study was approved by Ethics Review Committee of Jiangsu Provincial Center for Disease Control and Prevention and followed the tenets the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Associations of Insulin Levels and Insulin Resistance With Urine Glucose Excretion Independent of Blood Glucose in Chinese Adults With Prediabetes and Newly Diagnosed Diabetes

et al. 2018

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Several studies have demonstrated that renal glucose reabsorption is increased in patients with type 2 diabetes. However, the increased renal glucose reabsorption may contribute to the progression of hyperglycemia. Therefore, promoting urine glucose excretion (UGE) by suppression of renal glucose reabsorption is an attractive approach for the treatment of diabetes. Insulin resistance is identified as a major characteristic in the pathogenesis of type 2 diabetes. Thus, our aim was to evaluate the association of UGE with serum insulin levels and insulin resistance in subjects with glucose abnormalities, including prediabetes and newly diagnosed diabetes (NDD). The present study included 1129 subjects, 826 individuals with prediabetes and 303 individuals with NDD. Urine samples were collected within 2 h of oral glucose loading for the measurement of glucose. Fasting serum insulin was measured. Homeostatic model assessment of insulin resistance (HOMA-IR) was assessed. Multiple linear regression analysis and multivariate logistic regression analysis were performed to determine the association of UGE with insulin levels and HOMA-IR. A negative association between serum insulin levels and UGE was observed. The relationship remained significant after adjustment for potential confounders, including age, gender, blood pressure and glucose (β = -5.271, 95% CI: -9.775 to -0.767, p = 0.022). Furthermore, multivariable logistic regression model showed that increased insulin levels were associated with a decreased risk for high UGE after multivariable adjustment. In addition, similar correlation was also observed between HOMA-IR and UGE. HOMA-IR was negatively correlated with UGE after controlling for potential confounders. Moreover, an independent inverse relationship between HOMA-IR and the risk of high UGE was found (OR = 0.85, 95% CI: 0.78–0.93, p < 0.001). In conclusion, insulin levels and HOMA-IR were negatively correlated with UGE after adjusting for potential confounders. Subjects with increased insulin levels or IR were at a decreased risk of high UGE independent of blood glucose. The study suggests that insulin might affect UGE through other ways, in addition to the direct blood glucose-lowering effect, thereby resulting in reduced UGE.

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Identification of Newly Diagnosed Diabetes and Prediabetes Using Fasting Plasma Glucose and Urinary Glucose in a Chinese Population

Cited by 17 publications

References 26 publications

Use of capillary glucose combined with other non‐laboratory examinations to screen for diabetes and prediabetes

Use of capillary glucose combined with other non‐laboratory examinations to screen for diabetes and prediabetes

Increased urinary glucose excretion is associated with a reduced risk of hyperuricaemia

Associations of Insulin Levels and Insulin Resistance With Urine Glucose Excretion Independent of Blood Glucose in Chinese Adults With Prediabetes and Newly Diagnosed Diabetes

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