Identification of non-host semiochemicals for the brown dog tick, Rhipicephalus sanguineus sensu lato (Acari: Ixodidae), from tick-resistant beagles, Canis lupus familiaris

Borges, Lígia Miranda Ferreira; Filho, Jaires Gomes de Oliveira; Ferreira, Lorena Lopes; Louly, Carla Cristina Braz; Pickett, John A.; Birkett, Michael A.

doi:10.1016/j.ttbdis.2015.05.014

Cited by 32 publications

(46 citation statements)

References 46 publications

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“…In olfactometer tests, comparing the odours from both breeds, ticks were observed to avoid the odour of beagles. This avoidance behaviour elicited by resistant dogs was found to be associated with two compounds, 2hexanone and benzaldehyde, found in their odours, which act as natural tick repellents [14].…”

Section: Introductionmentioning

confidence: 98%

“…The brown dog tick, Rhipicephalus sanguineus sensu lato, is a serious pest of concern to public health and also of veterinary importance for animals at risk [9][10][11][12]. R. sanguineus utilizes volatile semiochemicals present in breath, skin of its hosts as a mode of host location [13,14]. Louly et al [15] demonstrated that a higher number of R. sanguineus s. l. ticks were recovered in English cocker spaniel than beagles, and later demonstrated that R. sanguinueus s. l. uses chemoreception when choosing between either resistant (beagle), or susceptible (English cocker spaniel), dogs as hosts.…”

Section: Introductionmentioning

confidence: 99%

“…A desirable approach is the integration of biological technologies and volatile compounds that alter tick behavior [21]. Borges et al [14] found compounds in resistant beagle dogs that could be used in such an approach. However, it has been observed in resistant and susceptible hosts that the naturally occurring association of chemical compounds can blind, mask, or expand the perception of other chemical compounds acting as signals to parasites [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Quantification of brown dog tick repellents, 2-hexanone and benzaldehyde, and release from tick-resistant beagles, Canis lupus familiaris

Filho

Sarria

Ferreira

et al. 2016

Journal of Chromatography B

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We have recently shown that repellency of the tick Rhipicephalus sanguineus sensu lato by the tick resistant dog breed, the beagle, is mediated by volatile organic compounds (VOCs) 2-hexanone and benzaldehyde present in beagle odour. Ectoparasite location of animal hosts is affected by variation in these odour components and their ratios. The aim of this study was to quantify the release rate, and the ratio, of 2-hexanone and benzaldehyde from beagles. The odour of three beagles was collected, for four days, over one week (day 0, day 1, day 4 and day 7). The compounds were identified using coupled high-resolution gas chromatography-mass spectrometry (GC-MS), and authentic standards of compounds were used to generate external calibration curves for quantification. Both compounds were found in all dogs on all days. The amount of benzaldehyde was always higher than that of 2-hexanone and so their ratio varied from unity, on average (over time) being 3.128±0.365, 1.902±0.390, 1.670±0.671ngmL(-1) for beagle 1, 2 and 3, respectively. There was no significant (p<0.05, F-test) effect of time. The overall mean was 2.233±0.387ngmL(-1). These results further previous findings by documenting the presence of 2-hexanone and benzaldehyde in beagle odour samples covering a 7-day period. This knowledge enables development of repellents to protect dogs from R. sanguineus s. l. infestation.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantification of brown dog tick repellents, 2-hexanone and benzaldehyde, and release from tick-resistant beagles, Canis lupus familiaris

Filho

Sarria

Ferreira

et al. 2016

Journal of Chromatography B

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“…R. sanguineus was shown to discriminate substances from dogs to differentiate susceptible English Cocker Spaniels from resistant Beagles (Louly et al, 2010). Benzaldehyde and 2-hexanone were identified in Beagle odor extracts and, when used in combination, repelled R. sanguineus in vitro (Borges et al, 2015). A repellent formulation of these…”

Section: Integrated Tick Managementmentioning

confidence: 99%

“…Benzaldehyde and 2‐hexanone were identified in Beagle odor extracts and, when used in combination, repelled R . sanguineus in vitro (Borges et al., ). A repellent formulation of these compounds could be used as part of the repertoire for integrated R .…”

Section: Introductionmentioning

confidence: 99%

Translating Ecology, Physiology, Biochemistry, and Population Genetics Research to Meet the Challenge of Tick and Tick‐borne Diseases in North America

Esteve-Gassent

Castro-Arellano

Feria-Arroyo

et al. 2016

Arch Insect Biochem Physiol

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Emerging and re-emerging tick-borne diseases threaten public health and the wellbeing of domestic animals and wildlife globally. The adoption of an evolutionary ecology framework aimed to diminish the impact of tick-borne diseases needs to be part of strategies to protect human and animal populations. We present a review of current knowledge on the adaptation of ticks to their environment, and the impact that global change could have on their geographic distribution in North America. Environmental pressures will affect tick population genetics by selecting genotypes able to withstand new and changing environments and by altering the connectivity and isolation of several tick populations. Research in these areas is particularly lacking in the southern US and most of Mexico with knowledge gaps on the ecology of these diseases, including a void in the identity of reservoir hosts for several tick-borne pathogens. Additionally, the way in which anthropogenic changes to landscapes may influence tick-borne disease ecology remains to be fully understood. Enhanced knowledge in these areas is needed in order to implement effective and sustainable integrated tick management strategies. We propose to refocus ecology studies with emphasis on metacommunity-based approaches to enable a holistic perspective addressing whole pathogen and host assemblages. Network analyses could be used to develop mechanistic models involving multi host-pathogen communities. An increase in our understanding of the ecology of tick-borne diseases across their geographic distribution will aid in the design of effective area-wide tick control strategies aimed to diminish the burden of pathogens transmitted by ticks.

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How Equids Cope with Macroparasites

Tombak

Rubenstein

2023

Fascinating Life Sciences

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Identification of non-host semiochemicals for the brown dog tick, Rhipicephalus sanguineus sensu lato (Acari: Ixodidae), from tick-resistant beagles, Canis lupus familiaris

Cited by 32 publications

References 46 publications

Quantification of brown dog tick repellents, 2-hexanone and benzaldehyde, and release from tick-resistant beagles, Canis lupus familiaris

Quantification of brown dog tick repellents, 2-hexanone and benzaldehyde, and release from tick-resistant beagles, Canis lupus familiaris

Translating Ecology, Physiology, Biochemistry, and Population Genetics Research to Meet the Challenge of Tick and Tick‐borne Diseases in North America

How Equids Cope with Macroparasites

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