Identification of Novel Function of Vimentin for Quality Standard for Regenerated Pulp Tissue

Murakami, Masashi; Imabayashi, Kiyomi; Watanabe, Atsushi; Takeuchi, Norio; Ishizaka, Ryo; Iohara, Koichiro; Yamamoto, Takashi; Nakamura, Hiroshi; Nakashima, Mitsuyoshi

doi:10.1016/j.joen.2012.01.010

Cited by 19 publications

(13 citation statements)

References 30 publications

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“…Vimentin has emerged as an organizer of a number of critical proteins involved in cell attachment, migration, and signaling. Recent studies have revealed several key functions for vimentin [22][23][24]. In particular, a previous study reported that vimentin-deficient fibroblasts exhibited markedly reduced collagen synthesis, which is consistent with the impaired wound healing observed in vimentin knockout mice [25].…”

Section: Discussionsupporting

confidence: 56%

“…Previous studies have shown the effectiveness of pneumatic devices in the treatment of acne scars [20], herpes zoster-induced depressed scars [21], and tissue necrosis following filler injection using subdermal minimal surgery technology [22]. Furthermore, these devices can be used to treat and flatten hypertrophic scars of the forehead and post-thyroidectomy scars [23,24]. Both Airgent TM and INNOJECTOR TM are safe, long-term skin remodeling treatments that reverse the visible signs of aging and make the skin appear younger immediately following treatment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model

Kwon

Seok

Jang

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model

Kwon

Seok

Jang

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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“…Only one project was selected in the field of dentistry: “The application of new treatments for dental caries/pulpitis through dentine/pulp regeneration using pulp stem cells” (representative of this special project: Dr. Misako Nakashima, Director, National Center for Geriatrics and Gerontology, Oobu City, Aichi, Japan). The basic principle of this research is to apply regenerative medicine using pulp stem cells, GCSF, and collagen solution to treat empty pulp extirpated cavities in patients with a history of pulpectomy and infected root canal treatment [76–86]. …”

Section: Application For Use As a Biomaterialsmentioning

confidence: 99%

Potency of Fish Collagen as a Scaffold for Regenerative Medicine

Yamada

Yamamoto

Ikeda

et al. 2014

BioMed Research International

171

114

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Cells, growth factors, and scaffold are the crucial factors for tissue engineering. Recently, scaffolds consisting of natural polymers, such as collagen and gelatin, bioabsorbable synthetic polymers, such as polylactic acid and polyglycolic acid, and inorganic materials, such as hydroxyapatite, as well as composite materials have been rapidly developed. In particular, collagen is the most promising material for tissue engineering due to its biocompatibility and biodegradability. Collagen contains specific cell adhesion domains, including the arginine-glycine-aspartic acid (RGD) motif. After the integrin receptor on the cell surface binds to the RGD motif on the collagen molecule, cell adhesion is actively induced. This interaction contributes to the promotion of cell growth and differentiation and the regulation of various cell functions. However, it is difficult to use a pure collagen scaffold as a tissue engineering material due to its low mechanical strength. In order to make up for this disadvantage, collagen scaffolds are often modified using a cross-linker, such as gamma irradiation and carbodiimide. Taking into account the possibility of zoonosis, a variety of recent reports have been documented using fish collagen scaffolds. We herein review the potency of fish collagen scaffolds as well as associated problems to be addressed for use in regenerative medicine.

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“…Some researchers have suggested the requirements and standards for using cell therapy to treat dental problems (Murakami et al, 2012;Nakashima and Iohara, 2014). Dimitrova-Nakov et al (2014) indicated that DPSCs can be induced to generate dentin, demonstrating the possibility of using DPCs to repair damaged teeth.…”

Section: Introductionmentioning

confidence: 99%

Mucus of Achatina fulica stimulates mineralization and inflammatoryresponse in dental pulp cells

Kantawong

Thaweenan²,

Mungkala³

et al. 2016

Turk J Biol

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IntroductionDental and oral diseases are major concerns in Thailand, affecting the country's health system. Everyone, at any age, is at risk of losing teeth. Tooth loss can lead to many health problems, including difficulty chewing, which increases the risk of poor nutrition. In addition, tooth loss leaves a large gap, leading to plaque accumulation that can cause periodontal disease. Moreover, the remaining teeth start to shift in an attempt to fill in the gap, leading to misalignment of teeth. Losing teeth may also affect personality, including a loss of confidence that may affect work or social activities. Restoration, with dentures or dental implants, is needed to replace the missing teeth.Current research has focused on dental and bone implants capable of promoting cell differentiation Xavier Acasigua et al., 2014;Naddeo et al., 2015). Cells isolated from tooth pulp contain odontoblasts, fibroblasts, immune cells, and undifferentiated mesenchymal cells called dental pulp stem cells (DPSCs). These findings may lead to restoration using dental pulp cells (DPCs), together with dental implants, to replace lost teeth. Various research groups have proposed the possibility of producing bioactive dental implants by adding natural products, such as natural hydroxyapatite/ zircon (Karamian et al., 2014), plant products (Varoni et al., 2012), or herbal extracts (Wang et al., 2012), to dental materials.Snails have been used in medicine since ancient times. Until the late 19th century, the synthetic peptide ziconotide (SNXIII), which is found in the venom of Conus magus, was used as a painkiller following approval by the United States Food and Drug Administration (Bonnemain, 2005). According to reports, snails contain several medically useful substances, including mytimacinlike antimicrobial peptides, which are exclusively found in the mucus of giant African snails (Zhong et al., 2013). In addition, lectin, which acts as an antimicrobial, is also present in the mucus of giant African snails (Ito et al., 2011). High-performance liquid chromatography was used to determine the amount of allantoin and glycolic Abstract: Dental pulp tissue contains stem cells that can be isolated and used for regenerative medicine in tooth restoration or autologous transplantation. The aim of this study was to observe the mineralization and gene expression in dental pulp cells (DPCs) following treatment with snail mucus. Snail mucus was collected from adult Achatina fulica and processed as a dry powder by the freeze-drying technique. The mucus powder was dissolved in a culture medium at a concentration of 15 µg/mL. DPCs were prepared by the outgrowth technique and cultured in a 6-well plate at a density of 5 × 10 4 cells per well. A mucus-supplemented medium (15 µg/mL) was added to each well. Cell culture was maintained for 3 weeks. The results of Alizarin Red S staining indicated that the DPCs cultured in a medium supplemented with snail mucus showed a higher number of mineralized nodules as compared with the control group cultured in a norm...

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Identification of Novel Function of Vimentin for Quality Standard for Regenerated Pulp Tissue

Cited by 19 publications

References 30 publications

Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model

Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model

Potency of Fish Collagen as a Scaffold for Regenerative Medicine

Mucus of Achatina fulica stimulates mineralization and inflammatoryresponse in dental pulp cells

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