2001
DOI: 10.4049/jimmunol.166.8.5058
|View full text |Cite
|
Sign up to set email alerts
|

Identification of Novel Functional Regions Important for the Activity of HOXB7 in Mammalian Cells

Abstract: Members of the HOX family of homeobox transcription factors play a role in pattern formation in diverse developmental systems. The clearly documented role of HOX genes in the proliferation and differentiation of primary hematopoietic cells and cell lines provides a convenient system to pursue a biochemical analysis of HOX gene function in mammalian cells. To explore the role of HOXB7 in myeloid hematopoiesis, a number of mutations and deletions in the gene were constructed that targeted sequences with known fu… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
39
0

Year Published

2001
2001
2022
2022

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 39 publications
(40 citation statements)
references
References 44 publications
1
39
0
Order By: Relevance
“…Identifying such transcriptional mechanisms must await the identi®cation of target genes whose transcription is directly controlled by overexpressed HoxB8. This type of non-speci®c disruption of developmental fate by inappropriate Hox protein expression, which is also observed for HoxB7 in terms of its Pbx-dependent mechanism of preventing G-CSF-induced neutrophil di erentiation of 32D cells (Yaron et al, 2001) is similar to the observation in Drosophila that expression of Abd-A and Abd-B, which play speci®c roles in de®ning thoracic identity, transforms wing into haltere without producing any qualities of the thorax.…”
Section: Discussionsupporting
confidence: 60%
See 1 more Smart Citation
“…Identifying such transcriptional mechanisms must await the identi®cation of target genes whose transcription is directly controlled by overexpressed HoxB8. This type of non-speci®c disruption of developmental fate by inappropriate Hox protein expression, which is also observed for HoxB7 in terms of its Pbx-dependent mechanism of preventing G-CSF-induced neutrophil di erentiation of 32D cells (Yaron et al, 2001) is similar to the observation in Drosophila that expression of Abd-A and Abd-B, which play speci®c roles in de®ning thoracic identity, transforms wing into haltere without producing any qualities of the thorax.…”
Section: Discussionsupporting
confidence: 60%
“…In the case of HoxB3 and HoxB4, the magnitude of their oncogenic function in Rat-1 ®broblast (number and size of colonies in soft agar) is augmented by co-expression of Pbx1 , providing indirect evidence that heterodimerization with endogenous Pbx may be essential for their transforming properties. In the case of HoxB7, its ability to prevent G-CSF-induced granulocytic di erentiation of 32D cells requires its hexapeptide Pbx-interaction motif (Yaron et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…The conserved Ser −1 is projected away from the DNA along with Thr 1 in the linker. Because this Ser is a protein kinase C phosphorylation consensus site and several homeodomains are shown to be regulated by phosphorylation (Jaffe et al 1997;Berry and Gehring 2000;Eklund et al 2000;Yaron et al 2001), there is a possibility that this residue is conserved because it is required for phosphorylation-mediated regulation.…”
Section: The Variant Hoxa9 Hexapeptide and Three-amino-acid Linkermentioning
confidence: 99%
“…These Pbx1 has also been implicated in the development of several tumors including hematological malignancies (Kamps et al, 1990(Kamps et al, , 1991Nourse et al, 1990;Qiu et al, Shiraishi et al, 2007;Park et al, 2008). It is required for the execution of some Hox-dependent block of differentiation, and/or transformation (Krosl et al, 1998;Knoepfler et al, 2001;Yaron et al, 2001), and mutations of HoxA9 that prevent interaction with Pbx proteins abrogate its oncogenic properties (Schnabel et al, 2000). Notably, Evi-1 also cooperates with Hoxa and Meis1 in myeloid leukemogenesis (Jin et al, 2007).…”
Section: Evi-1 Activates Pbx1 Transcription M Shimabe Et Almentioning
confidence: 99%