Identification of novel indole derivatives as highly potent AMPK activators with anti-diabetic profiles

Tamura, Yoshinori; Morita, Ippei; Hinata, Yu; Kojima, Eiichi; Ozasa, Hiroki; Ikemoto, Hidaka; Asano, Mutsumi; Wada, Toshihiro; Hayasaki-Kajiwara, Yoko; Iwasaki, Takanori; Matsumura, Ken‐ichi

doi:10.1016/j.bmcl.2022.128769

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…Other potential antimalarial candidates with the indolyl scaffold have also been reported [17][18][19][20]. Anti-diabetic [21,22] and anti-inflammatory [23][24][25][26][27] properties have also been observed for indole derivatives. Figure 2 presents some of the indole-containing drugs approved for the treatment of a range of conditions [1,2,[28][29][30][31][32][33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 90%

Indole-based compounds as potential drug candidates for SARS-CoV-2

Girgis,

Panda,

Kariuki

et al. 2023

Preprint

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The COVID-19 pandemic has posed a significant threat to society in recent times, endangering human health, life, and economic well-being. The disease spreads quickly due to the highly infectious SARS-CoV-2 virus, which has undergone numerous mutations. Despite intense research efforts by the scientific community since its emergence in 2019, no effective therapeutics have been discovered yet. While some repurposed drugs have been used to control the global outbreak and save lives, none have proven universally effective, particularly for severely infected patients. Although the spread of the disease is generally under control, anti-SARS-CoV-2 agents are still needed to combat current and future infections. This study reviews some of the most promising repurposed drugs containing indolyl heterocycle, which is an essential scaffold of many alkaloids with diverse bio-properties in various biological fields. The study also discusses natural and synthetic indole-containing compounds with anti-SARS-CoV-2 properties, as well as computer-aided drug design (in-silico studies) for optimizing anti-SARS-CoV-2 hits/leads.

show abstract

Section: Introductionmentioning

confidence: 90%

Indole-based compounds as potential drug candidates for SARS-CoV-2

Girgis,

Panda,

Kariuki

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Other potential antimalarial candidates with the indolyl scaffold have also been reported [ 17 , 18 , 19 , 20 ]. Anti-diabetic [ 21 , 22 ] and anti-inflammatory [ 23 , 24 , 25 , 26 , 27 ] properties have also been observed for indole derivatives. Figure 2 presents some of the indole-containing drugs approved for the treatment of a range of conditions [ 1 , 2 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

Girgis,

Panda,

Kariuki

et al. 2023

Molecules

View full text Add to dashboard Cite

The COVID-19 pandemic has posed a significant threat to society in recent times, endangering human health, life, and economic well-being. The disease quickly spreads due to the highly infectious SARS-CoV-2 virus, which has undergone numerous mutations. Despite intense research efforts by the scientific community since its emergence in 2019, no effective therapeutics have been discovered yet. While some repurposed drugs have been used to control the global outbreak and save lives, none have proven universally effective, particularly for severely infected patients. Although the spread of the disease is generally under control, anti-SARS-CoV-2 agents are still needed to combat current and future infections. This study reviews some of the most promising repurposed drugs containing indolyl heterocycle, which is an essential scaffold of many alkaloids with diverse bio-properties in various biological fields. The study also discusses natural and synthetic indole-containing compounds with anti-SARS-CoV-2 properties and computer-aided drug design (in silico studies) for optimizing anti-SARS-CoV-2 hits/leads.

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“…5 It is widely distributed in plants such as Isatidis radix , 6 Euodia rutaecarp a, 7 Rauvolfia serpentina , 8 and Catharanthus roseus . 9 Indole derivatives have a variety of pharmacological activities, 10 including anti-tumor, 11,12 anti-inflammatory, 13–15 anti-oxidant, 14–17 anti-Alzheimer's, 18 and anti-diabetic 19 activities; therefore, the indole ring plays an important role in the development of new agents. In addition, there are many agents containing indole structures, such as osimertinib, vincristine (VCR), reserpine, tadalafil, fluvastatin, indomethacin, zafirlukast and delavirdine which have been used in clinical research (Fig.…”

Section: Introductionmentioning

confidence: 99%