Identification of novel metabolic signatures potentially involved in the pathogenesis of COPD associated pulmonary hypertension

Choudhury, Priyanka; Bhattacharya, A.; Dasgupta, Sanjukta; Ghosh, Nilanjana; Senpupta, Sayoni; Bhattacharyya, Parthasarathi; Chaudhury, Koel

doi:10.1007/s11306-021-01845-9

Cited by 8 publications

(4 citation statements)

References 53 publications

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“…Also chronic obstructive pulmonary disease-associated PH, one of the most common subtypes of the disease, is classified in Group 3. A metabolomic analysis carried out with 1 H nuclear magnetic resonance spectroscopy on serum and exhaled breath condensate detected unbalanced lactate and pyruvate levels in both fluids, which were linked to the pulmonary artery pressure calculated during echocardiography [30]. Chronic exposure to high altitude can cause PH development.…”

Section: Specific Ph Subtypesmentioning

confidence: 95%

Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

Bassareo,

D’Alto

2023

IJMS

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Pulmonary hypertension (PH) is a multifaceted illness causing clinical manifestations like dyspnea, fatigue, and cyanosis. If left untreated, it often evolves into irreversible pulmonary arterial hypertension (PAH), leading to death. Metabolomics is a laboratory technique capable of providing insights into the metabolic pathways that are responsible for a number of physiologic or pathologic events through the analysis of a biological fluid (such as blood, urine, and sputum) using proton nuclear magnetic resonance spectroscopy or mass spectrometry. A systematic review was finalized according to the PRISMA scheme, with the goal of providing an overview of the research papers released up to now on the application of metabolomics to PH/PAH. So, eighty-five papers were identified, of which twenty-four concerning PH, and sixty-one regarding PAH. We found that, from a metabolic standpoint, the hallmarks of the disease onset and progression are an increase in glycolysis and impaired mitochondrial respiration. Oxidation is exacerbated as well. Specific metabolic fingerprints allow the characterization of some of the specific PH and PAH subtypes. Overall, metabolomics provides insights into the biological processes happening in the body of a subject suffering from PH/PAH. The disarranged metabolic pathways underpinning the disease may be the target of new therapeutic agents. Metabolomics will allow investigators to make a step forward towards personalized medicine.

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Section: Specific Ph Subtypesmentioning

confidence: 95%

Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

Bassareo,

D’Alto

2023

IJMS

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“…Lactate and pyruvate were found to be significantly altered in both the biofluids, and showed significant correlation with echocardiographic sPAP. 121 As mentioned earlier, limited treatment options are available for most of the PH groups. However, CTEPH is a notable exception with PEA surgery often proving curative.…”

Section: Metabolomics In Phmentioning

confidence: 99%

“…Lactate and pyruvate were found to be significantly altered in both the biofluids, and showed significant correlation with echocardiographic sPAP. 121…”

Section: Metabolomics In Phmentioning

confidence: 99%

Understanding pulmonary hypertension: the need for an integrative metabolomics and transcriptomics approach

Choudhury,

Dasgupta,

Bhattacharyya

et al. 2024

Mol. Omics

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“…In addition, as bisphenol A is poorly soluble in water, the presence in blood can result from high levels in drinking water [92]. Finally, it should be pointed out that a number of different factors need to be considered when undertaking metabolomic studies, including diet [110] and comorbidities [111][112][113][114][115][116][117][118][119]. In this regard, obesity [111,112], chronic obstructive pulmonary disease [113][114][115], kidney disease [116], diabetes [117,118], and cardiovascular disease [94] have all been reported to have a major impact on the metabolome that can confound metabolomic studies in cancer, and thus, their influence cannot be underestimated.…”

Section: Effect Of Underlying Diseases or Non-related Metabolitesmentioning

confidence: 99%

Metabolomic Fingerprinting for the Detection of Early-Stage Lung Cancer: From the Genome to the Metabolome

Haince¹,

Joubert

Bach

et al. 2022

IJMS

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The five-year survival rate of lung cancer patients is very low, mainly because most newly diagnosed patients present with locally advanced or metastatic disease. Therefore, early diagnosis is key to the successful treatment and management of lung cancer. Unfortunately, early detection methods of lung cancer are not ideal. In this brief review, we described early detection methods such as chest X-rays followed by bronchoscopy, sputum analysis followed by cytological analysis, and low-dose computed tomography (LDCT). In addition, we discussed the potential of metabolomic fingerprinting, compared to that of other biomarkers, including molecular targets, as a low-cost, high-throughput blood-based test that is both feasible and affordable for early-stage lung cancer screening of at-risk populations. Accordingly, we proposed a paradigm shift to metabolomics as an alternative to molecular and proteomic-based markers in lung cancer screening, which will enable blood-based routine testing and be accessible to those patients at the highest risk for lung cancer.

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Identification of novel metabolic signatures potentially involved in the pathogenesis of COPD associated pulmonary hypertension

Cited by 8 publications

References 53 publications

Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

Understanding pulmonary hypertension: the need for an integrative metabolomics and transcriptomics approach

Metabolomic Fingerprinting for the Detection of Early-Stage Lung Cancer: From the Genome to the Metabolome

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