2015
DOI: 10.1186/s12977-015-0184-2
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Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms

Abstract: BackgroundHuman T cell leukemia virus type 1 (HTLV-1) gene expression is controlled by the key regulatory proteins Tax and Rex. The concerted action of these proteins results in a two-phase kinetics of viral expression that depends on a time delay between their action. However, it is difficult to explain this delay, as Tax and Rex are produced from the same mRNA. In the present study we investigated whether HTLV-1 may produce novel mRNA species capable of expressing Rex and Tax independently.FindingsResults re… Show more

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Cited by 4 publications
(8 citation statements)
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“…2B). These findings are consistent with our previous observations identifying these transcripts as "late" mRNAs (9,25). Interestingly, some transcripts were highly dependent on Rex (e.g., gag, p13, and env), while others (e.g., p12/p8 and rex c ) were less Rex dependent, suggesting that the expression of the different transcripts is graded rather than an all-or-nothing phenomenon.…”
Section: Resultssupporting
confidence: 81%
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“…2B). These findings are consistent with our previous observations identifying these transcripts as "late" mRNAs (9,25). Interestingly, some transcripts were highly dependent on Rex (e.g., gag, p13, and env), while others (e.g., p12/p8 and rex c ) were less Rex dependent, suggesting that the expression of the different transcripts is graded rather than an all-or-nothing phenomenon.…”
Section: Resultssupporting
confidence: 81%
“…Our findings are consistent with the intermediate-late temporal pattern of expression of the p30tof, p13, p12/8, rex b , and rex c mRNAs described in our previous studies (9,25) based on the ex vivo reactivation of primary cells isolated from HTLV-1-infected patients; in contrast, p21rex and tax a /rex a were expressed as early genes, supporting their Rex independence (9,25). On the other hand, our observations in part contradict the results of a recent study by Li et al that showed that expression of the p13, p21rex, p12/p8, and p30tof mRNAs is not affected by Rex in 293T cells (38).…”
Section: Discussionsupporting
confidence: 81%
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“…These observations suggest that viral mRNA export is under a more complex regulation than previously thought. Furthermore, another recent study has suggested that there are three alternatively spliced HTLV-1 transcripts that encode for novel Rex isoforms, which may also contribute to the regulation of HTLV-1 protein expression levels [ 80 ].…”
Section: Htlv-1 Infectious Replication Cyclementioning
confidence: 99%