Identification of novel mutations in β-thalassemia patients in Maysan Governorate, Iraq

AL-hameedawi, Abbas Kadhim Jiheel; Al-Shawi, Ali A. A.

doi:10.1007/s11033-023-08271-1

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…In individuals with β-thalassemia major, myocardial damage is the primary predictor of survival 18,19 . Myocardial iron overload therapy options are now limited to a select group of ironchelation techniques, with a number of limitations brought on by the need for high doses and their associated side effects 20 . The current research included studying the biochemical parameters of heart disorders for patients with β-thalassemia major and comparing them with the healthy control group to discover the extent to which the heart is affected by iron overload produced as a complication of blood transfusion for β-thalassemia patients.…”

Section: Discussionmentioning

confidence: 99%

تقييم بعض انزيمات القلب والحديد في مصل مرضى بيتا-ثلاسيميا في مدينة ذي قار ، العراق

Ibrahim,

AL–Saeed

2024

Baghdad Sci.J

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Beta thalassemia is one of the most common hereditary diseases in the world caused by a deficiency of globin chains. Heart disease is one of the main complications of this disease as a result of excess iron deposition in the cardiac tissues. Total of 100 patients of 2-18 years diagnosed with ß-TM were employed in the current study and admitted to Thi-Qar Center of Hereditary Blood Diseases in Thi-Qar city, Iraq, and 80 healthy participants, matched by age, and geographical area were adopted as control group. The current study included evaluating of serum Troponin I (c.TnI), Creatine kinase-MB isoenzyme (CK-MB), Apelin, aspartate aminotransferase (AST), and Lactate Dehydrogenase enzyme (LDH) of studied groups. The finding revealed a significant increase (p<0.01) of c.TnI, CK-MB, AST, and LDH levels as well as a significant decrease (p<0.01) in apelin level in all patients with ß-TM compared to the control group. Pearson's correlation coefficient (r) was also found between the biochemical parameters studied for ß-TM patients with ferritin level, were found a significant correlation (p<0.01) between ferritin level with CK-MB, LDH, and AST levels while there was no significant correlation (P>0.01) through apelin and c.TnI levels. The finding showed a clinical predictor to damage cardiac tissues in the near term, which portends the use of more efficient treatment protocols to remove excess iron from ß-TM patients.

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Section: Discussionmentioning

confidence: 99%

تقييم بعض انزيمات القلب والحديد في مصل مرضى بيتا-ثلاسيميا في مدينة ذي قار ، العراق

Ibrahim,

AL–Saeed

2024

Baghdad Sci.J

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“…The vaccines for RVFV are available only for animals, particularly in both endemic and non-endemic areas. Additionally, despite the availability of supportive medication for managing mild cases of RVFV infection, there is currently no specific antiviral treatment and vaccine for humans [28,29]. These limitations highlight the pressing need for regular monitoring of both animals and humans, specifically slaughterhouse workers and locals within the outbreak zone of 2000 and other parts of Saudi Arabia.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2024

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The author's state that they adhere with COPE guidelines on publishing ethics as described elsewhere at https://publicationethics.org/. The authors also undertake that they are not associated with any other third party (governmental or non-governmental agencies) linking with any form of unethical issues connecting to this publication. The authors also declare that they are not withholding any information that is misleading to the publisher in regard to this article.

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Does TNF-α 308 G/A (rs1800629) gene polymorphism associate with liver and pancreas disorders in Iraqi adults with beta thalassemia major?

Luaibi,

Mohammed

2024

HAB

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BACKGROUND: TNF-α has been considered as the key regulator of inflammatory responses and is known to be participated in the pathogenesis of several diseases. OBJECTIVE: The aim of this study was to explore the relationship of (rs1800629) gene polymorphism associated to liver and pancreas disorders in sample of β-thalassemia major adult Iraqi Patients. MATERIAL AND METHOD: Blood samples were obtained from 40 patients suffered from beta thalassemia with pancreas disorder, along with 40 patient suffered from thalassemia with liver disorder, and 40 patient suffered from thalassemia without pancreas or liver, from Ibn Al-Baladi Hospital, Baghdad, and 40 samples from age and gender-matched apparently healthy individuals as control group, all subjects with age more than 18 years. TNF-308G/A (rs1800629) gene polymorphisms were assessed by Tetra- ARMS-PCR. RESULTS: The result of showed that heterogeneous GA and homogeneous AA genotypes were higher, while GG wild genotype was lower in beta thalassemia major patients with liver and pancreas disorders compared to control group. CONCLUSION: It can be concluded that the prevalence of TNF-α 308 G/A SNP plus (A) allele could be associated with risk of liver and pancreas disorders in sample of beta thalassemia major adult.

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Identification of novel mutations in β-thalassemia patients in Maysan Governorate, Iraq

Cited by 5 publications

References 36 publications

تقييم بعض انزيمات القلب والحديد في مصل مرضى بيتا-ثلاسيميا في مدينة ذي قار ، العراق

تقييم بعض انزيمات القلب والحديد في مصل مرضى بيتا-ثلاسيميا في مدينة ذي قار ، العراق

Untitled

Does TNF-α 308 G/A (rs1800629) gene polymorphism associate with liver and pancreas disorders in Iraqi adults with beta thalassemia major?

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