2024
DOI: 10.1101/2024.09.27.615498
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Identification of novel toxin domains and characterization of a broadly distributed family of lipid-targeting NlpC/P60.

Gianlucca G Nicastro,
Stephanie Sibinelli-Sousa,
Julia Takuno Hespanhol
et al.

Abstract: Bacteria live in complex communities and use antagonistic strategies to compete for resources. Gram-negatives encode a type VI secretion system (T6SS) that delivers toxins into eukaryotic and prokaryotic cells. Previous studies highlighted the importance ofSalmonellaT6SSs in bacterial antagonism and host cell infection, but few antibacterial effectors have been described. Here, we used bioinformatic strategies to identify the T6SS effectors in 10,000Salmonellagenomes. As a result, we identified and manually cu… Show more

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