Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry

Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry

“…As an important traditional Chinese medicine (TCM), it showed bioactivities of anti-tumor [1], anti-hypertension [2], anti-shock [3], etc. Our preliminary studies indicated that main bioactive constituents of F. aurantii were flavonoids, especially some Odiglycosyl flavanones [4] and PMFs. Flavonoids are one of the most widespread groups of secondary plant metabolites.…”

Identification of components in Zhi-Zi-Da-Huang decoction by HPLC coupled with electrospray ionization tandem mass spectrometry, photodiode array and fluorescence detectors

“…The structural difference between each isomer was the substitution of different glycone in the same aglycone. According to literature [2,18] . The ion at m/z 151 was produced from a retro-Diels-Alder (RDA) fragmentation reaction cleaved at the C-ring of flavonoid aglycones (see Fig.…”

Practical guidelines for characterization of O‐diglycosyl flavonoid isomers by triple quadrupole MS and their applications for identification of some fruit juices flavonoids

“…[19,21,22] Liang et al characterized several O-dyglycosyl flavanones in Fructus aurantii by ESI-ITMS in positive and negative mode performing a preliminary study with standards in their own experimental conditions. [23] Therefore, it is clear that although the same trends and fragmentation are appreciated, specific studies in each configuration and different guidelines are needed in order to provide a satisfactory characterization of these flavonoids using only MS methods. [24] The aim of this work is the development of practical guidelines for the characterization of this same type of diglycosides using a triple quadrupole MS in positive mode and how they are applied to real samples.…”