Identification of PAQR3 as a new candidate tumor suppressor in hepatocellular carcinoma

Wu, Hong; Zhang, Wen Jie; Ding, Qi; Peng, Gang; Zou, Zhen; Liu, Ting; Cao, Ran; Fei, Shi Jiang; Li, Peng Cheng; Yang, Kun; Hu, Jian; Dai, Xiang; Wu, Gang; Li, Pin Dong

doi:10.3892/or.2014.3532

Cited by 33 publications

(18 citation statements)

References 15 publications

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“…Moreover, PAQR3 repressed cell proliferation, migration, sprouting, and angiogenesis of endothelial cells [13]. Furthermore, PAQR3 played a tumor suppressive role in the tumorigenesis of colorectal cancers, bladder cancer, and hepatocellular carcinoma [10,[16][17][18]. However, the role of PAQR3 in the LSCC remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma

Zhuang

2015

Tumor Biol.

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Laryngeal squamous cell carcinoma (LSCC) is a common type of head and neck malignancy worldwide. The molecular mechanism of LSCC remains not well understood. PAQR3 (progestin and AdipoQ receptors) is a member of the progestin and adipoQ receptor (PAQR) family. Many studies have showed that PAQR3 acts as a new tumor suppressor. However, its expression and functions in LSCC are still unknown. In our study, the expression of PAQR3 was downregulated in human LSCC tissues compared to that in adjacent tissues. Moreover, overexpression of PAQR3 suppressed LSCC cell proliferation and invasion. In addition, PAQR3 inhibited cell proliferation and invasion by regulating ERK phosphorylation. In conclusion, our data demonstrated that PAQR3 acted a tumor suppressive role in LSCC, providing a novel diagnostic and therapeutic option for LSCC in the future.

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Section: Introductionmentioning

confidence: 99%

“…PAQR3 belongs to the progesterone and adipoQ receptor (PAQR) family, which includes several members such as PAQR1, PAQR2, and PAQR3 [9][10][11]. PAQR3 composes of 7 transmembrane proteins, which is located at the Golgi apparatus.…”

Section: Introductionmentioning

confidence: 99%

PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma

Zhuang

2015

Tumor Biol.

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“…PAQR3 is considered a tumor suppressor gene in breast cancer, prostate cancer, ESCC, GC, colorectal cancer, hepatocellular carcinoma, 36,51 glioma, 52 leukemia, 53 etc. The details are summarized in Table 1.…”

Section: Paqr3 Represents a New Tumor Suppressor Genementioning

confidence: 99%

<p>Characterization of the Golgi scaffold protein PAQR3, and its role in tumor suppression and metabolic pathway compartmentalization</p>

Lan

Ling

Chen

et al. 2020

CMAR

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The Golgi apparatus is critical in the compartmentalization of signaling cascades originating from the cytoplasmic membrane and various organelles. Scaffold proteins, such as progestin and adipoQ receptor (PAQR)3, specifically regulate this process, and have recently been identified in the Golgi apparatus. PAQR3 belongs to the PAQR family, and was recently described as a tumor suppressor. Accumulating evidence demonstrates PAQR3 is downregulated in different cancers to suppress its inhibitory effects on malignant potential. PAQR3 functions biologically through the pathological regulation of altered signaling pathways. Significant cell proliferation networks, including Ras proto-oncogene (Ras)/mitogenactivated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), insulin, and vascular endothelial growth factor, are closely controlled by PAQR3 for physiologically relevant effects. Meanwhile, genetic/epigenetic susceptibility and environmental factors, may have functions in the downregulation of PAQR3 in human cancers. This study aimed to assess the subcellular localization of PAQR3 and determine its topological features and functional domains, summarizing its effects on cell signaling compartmentalization. The pathophysiological functions of PAQR3 in cancer pathogenesis, metabolic diseases, and developmental ailments were also highlighted.

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“…In experiments in nude mice with colorectal cancer, it was verified that PAQR3 plays a role in cancer inhibition in colorectal cancer tissues, and the deficiency of PAQR3 expression reduced the survival time of gene-knockout nude mice (4). In addition, a low expression of PAQR3 in tumor tissues of gastric cancer, breast cancer, melanoma and liver cancer has been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…PAQR3 is a cancer suppressor gene and is involved in various signal channels that can influence biological processes such as energy metabolism, cell proliferation, differentiation and the maturity of reproductive cells, and can negatively regulate the Ras/Raf/MEK/ERK signal channel (4). In experiments in nude mice with colorectal cancer, it was verified that PAQR3 plays a role in cancer inhibition in colorectal cancer tissues, and the deficiency of PAQR3 expression reduced the survival time of gene-knockout nude mice (4).…”

Section: Introductionmentioning

confidence: 99%

PAQR3 gene expression and its methylation level in colorectal cancer tissues

Zhang

et al. 2016

Oncology Letters

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The aim of the present study was to investigate the PAQR3 gene expression and its methylation level in colorectal cancer tissues, as well as the association with colorectal cancer clinical data. In total, 54 cases of colorectal cancer tissue samples and normal adjacent tissue samples were collected between June, 2013 and July, 2014. RT-PCR and western blot analysis were used to detect the mRNA and protein levels of PAQR3 in colorectal samples, respectively. MSP was used to detect the methylation level of PAQR3 gene in colorectal samples, which was compared with colorectal data. The results showed that a decreased expression level of PAQR3 mRNA in colorectal cancer tissues and the expression reduction rate was 57.4% (31/54). Similarly, the expression level of PAQR3 protein was reduced in cancer tissues, and the reduction rate was 46.3% (25/54), while the protein expression reduction rate in cancer adjacent tissue was 5.6% (3/54), and the difference was statistically significant (P<0.05). Furthermore, the methylation rates of PAQR3 in cancer tissues and cancer adjacent tissues were 33.3% (18/54) and 5.6% (3/54), respectively. In addition, PAQR3 mRNA and protein levels in colorectal cancer tissues were associated with the differentiation degree, lymphatic metastasis and tumor infiltration depth. The methylation level of PAQR3 was associated with age, differentiated degree, lymphatic metastasis and tumor infiltration depth. In conclusion, the expression of PAQR3 mRNA and protein in colorectal cancer was reduced and methylation of PAQR3 occurred. Although the PAQR3 mRNA and protein levels were not associated with gender, age or the location of tumor, there was an association with differentiation degree, lymphatic metastasis and tumor infiltration depth. In addition, the methylation level of PAQR3 was not correlated with gender or tumor location, but was correlated with age, differentiation degree, lymphatic metastasis and tumor infiltration depth.

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Identification of PAQR3 as a new candidate tumor suppressor in hepatocellular carcinoma

Cited by 33 publications

References 15 publications

PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma

PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma

<p>Characterization of the Golgi scaffold protein PAQR3, and its role in tumor suppression and metabolic pathway compartmentalization</p>

PAQR3 gene expression and its methylation level in colorectal cancer tissues

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