Identification of Parkinson’s disease-associated chromatin regulators

Abstract

Parkinson’s disease (PD) is a common neurological disorder that causes quiescent tremors, motor delays, depression, and sleep disturbances. Existing treatments can only improve symptoms, not stop progression or cure the disease, but effective treatments can significantly improve patients’ quality of life. There is growing evidence that chromatin regulatory proteins (CRs) are involved in a variety of biological processes, including inflammation, apoptosis, autophagy, and proliferation. But the relationship of chromatin regulators in Parkinson’s disease has not been studied. Therefore, we aim to investigate the role of CRs in the pathogenesis of Parkinson’s disease. We collected 870 chromatin regulatory factors from previous studies and downloaded data on patients with PD from the GEO database. 64 differentially expressed genes were screened, the interaction network was constructed and the key genes with the top 20 scores were calculated. Then we discussed its correlation with the immune function of PD. Finally, we screened potential drugs and miRNAs. Five genes related to the immune function of PD, BANF1, PCGF5, WDR5, RYBP and BRD2, were obtained by using the absolute value of correlation greater than 0.4. And the disease prediction model showed good predictive efficiency. We also screened 10 related drugs and 12 related miRNAs, which provided a reference for the treatment of PD. BANF1, PCGF5, WDR5, RYBP and BRD2 are related to the immune process of Parkinson’s disease and can predict the occurrence of Parkinson’s disease, which is expected to become a new target for the diagnosis and treatment of Parkinson’s disease.

MAPT Locus in Parkinson’s Disease Patients of Ashkenazi Origin: A Stratified Analysis

“…One of them is the partial duplication of the 5 ′ end of the KANSL1 gene [9]. KANSL1, part of the NSL complex, acts as a scaffolding protein [29] and interacts with the WD Repeat Domain 5 (WDR5) gene, which has been identified as being associated with the immune function of PD [30]. Both KANSL1 and lysine acetyltransferase 8 (KAT8) have been implicated in PINK1-dependent mitophagy [31], a cellular process involved in the degradation of dysfunctional mitochondria, which is associated with PD [32].…”