Identification of Patients with High-risk Lymph Node-negative Colorectal Cancer and Potential Benefit from Adjuvant Chemotherapy

Oñate‐Ocaña, Luis F.; Montesdeoca, Rene; López-Graniel, C.; Aiello-Crocifoglio, Vincenzo; Mondragón-Sánchez, Ricardo; Cortina‐Borja, Mario; Herrera‐Goepfert, Roberto; Oros-Ovalle, Cuauhtémoc; Gallardo‐Rincón, Dolores

doi:10.1093/jjco/hyh054

Cited by 29 publications

(24 citation statements)

References 17 publications

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“…In contrast to our results, other studies previously confirmed NI as a prognostic factor in colon cancer (28). However, most of these studies have quite low sample size, limited to certain tumor stages and do not distinguish between rectal and colon cancer, which represent biologically different cancer entities (27)(28)(29)(30).…”

Section: Discussioncontrasting

confidence: 99%

“…The invasion of peripheral nerves was neither mentioned nor examined in their study. In contrast, no other study in literature has included AuP in their definition of NI in colon cancer, which also results in lower NI prevalence rates (16,(28)(29)(30). This seems to be particularly important when one considers the association between AuP and NI in our study.…”

Section: Discussionmentioning

confidence: 88%

“…In nearly all studies concerning NI and colon cancer, NI has consistently been 1 out of several histopathologic features under investigation, but not the main focus of interest (16,29,30). In these studies, NI was not studied by reexamination of pathology specimens but rather by data collection from original pathology reports.…”

Section: Discussionmentioning

confidence: 99%

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The Severity of Neural Invasion Is Associated with Shortened Survival in Colon Cancer

Liebl

Demir

Rosenberg

et al. 2013

Clinical Cancer Research

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Purpose: Neural invasion (NI) is a histopathologic feature of colon cancer that receives little consideration. Therefore, we conducted a morphologic and functional characterization of NI in colon cancer.Experimental Design: NI was investigated in 673 patients with colon cancer. Localization and severity of NI was determined and related to patient's prognosis and survival. The neuro-affinity of colon cancer cells (HT29, HCT-116, SW620, and DLD-1) was compared with pancreatic cancer (T3M4 and SU86.86) and rectal cancer cells (CMT-93) in the in vitro three-dimensional (3D)-neural-migration assay and analyzed via live-cell imaging. Immunoreactivity of the neuroplasticity marker GAP-43, and the neurotrophic-chemoattractant factors Artemin and nerve growth factor (NGF), was quantified in colon cancer and pancreatic cancer nerves. Dorsal root ganglia of newborn rats were exposed to supernatants of colon cancer, rectal cancer, and pancreatic cancer cells and neurite density was determined.Results: NI was detected in 210 of 673 patients (31.2%). Although increasing NI severity scores were associated with a significantly poorer survival, presence of NI was not an independent prognostic factor in colon cancer. In the 3D migration assay, colon cancer and rectal cancer cells showed much less neuritetargeted migration when compared with pancreatic cancer cells. Supernatants of pancreatic cancer and rectal cancer cells induced a much higher neurite density than those of colon cancer cells. Accordingly, NGF, Artemin, and GAP-43 were much more pronounced in nerves in pancreatic cancer than in colon cancer.Conclusion: NI is not an independent prognostic factor in colon cancer. The lack of a considerable biologic affinity between colon cancer cells and neurons, the low expression profile of colonic nerves for chemoattractant molecules, and the absence of a major neuroplasticity in colon cancer may explain the low prevalence and impact of NI in colon cancer.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 88%

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The Severity of Neural Invasion Is Associated with Shortened Survival in Colon Cancer

Liebl

Demir

Rosenberg

et al. 2013

Clinical Cancer Research

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“…Age, gender, TNM stage, venous invasion, tumour necrosis, peri-tumoural lymphocytic infiltration, tumour budding and CEA levels were also independently associated with poor survival in at least some studies [17,18,21,22,26,30,32,33,39].…”

Section: Discussionmentioning

confidence: 96%

The role of perineural invasion in predicting survival in patients with primary operable colorectal cancer: A systematic review

Wyk

Going

Horgan

et al. 2017

Critical Reviews in Oncology/Hematology

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. (2017) The role of perineural invasion in predicting survival in patients with primary operable colorectal cancer: a systematic review. Critical Reviews in Oncology/Hematology, 112, pp. 11-20. (doi:10.1016/j.critrevonc.2017 This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/139181/ Therefore, the aim of the present study was to systematically review the identification and associations of perineural invasion and survival in patients with primary operable colorectal cancer. From initial search results of 912 articles, 38 studies were selected. Using H&E stains; five studies including 1835 patients reported on survival stratified by perineural invasion in colon cancer with weighted average detection rates of 26%; eleven studies including 3837 patients reported on rectal cancer with weighted average detection rates of 25% and; sixteen studies including 9145 patients reported on survival stratified by perineural invasion in colorectal cancer with weighted average detection rates of 17%. Using special techniques (S100), six studies including 1458 patients reported on the identification of perineural invasion in colorectal cancer.In comparison to H&E staining alone, the use of immunohistochemistry with S100 increased the detection of perineural invasion to approximately 70%.However, those studies did not examine the relationship with outcomes, so further research is required to establish the clinical significance of perineural invasion detected by immunohistochemistry. In conclusion, perineural invasion deserves special attention for improved prognostic stratification in patients with colorectal cancer. Further work is required to standardise pathology assessment and reporting of perineural invasion, in particular its definition, use of special stains and routine inclusion in pathology practice. Reliable assessment is required for investigations into mechanisms of perineural invasion, its role tumour spread and prognostic value.

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“…S everal reports have shown that perineural invasion (PNI) is an important prognostic factor in colorectal cancer [1][2][3][4][5] and rectal cancer. [6][7][8][9][10][11][12][13][14][15][16][17] Therefore, the colorectal working group of the American Joint Committee on Cancer (AJCC) prognostic factors consensus conference has classified PNI as category IIA, which means that PNI has been extensively studied biologically and/or clinically and is considered to have sufficient predictive value for outcome to be noted in pathology reports.…”

mentioning

confidence: 99%

Cancer Invasion to Auerbach's Plexus is an Important Prognostic Factor in Patients with pT3-pT4 Colorectal Cancer

Fujita¹,

Nakanisi²,

Taniguchi³

et al. 2007

Diseases of the Colon &Amp; Rectum

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Identification of Patients with High-risk Lymph Node-negative Colorectal Cancer and Potential Benefit from Adjuvant Chemotherapy

Abstract: Using these factors, a prognostic scale was developed to predict high risk of recurrence in cases of completely resected CRC and to identify them as a subgroup of patients with potential benefit of adjuvant chemotherapy.

Cited by 29 publications

References 17 publications

The Severity of Neural Invasion Is Associated with Shortened Survival in Colon Cancer

The Severity of Neural Invasion Is Associated with Shortened Survival in Colon Cancer

The role of perineural invasion in predicting survival in patients with primary operable colorectal cancer: A systematic review

Cancer Invasion to Auerbach's Plexus is an Important Prognostic Factor in Patients with pT3-pT4 Colorectal Cancer

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