Identification of peculiar and common effects of histone modifications on transcription

Liu, Yu; Li, Xue; Yang, Rongcun

doi:10.1016/j.jtbi.2015.04.040

Cited by 1 publication

(2 citation statements)

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“…Dysregulation of cytogenes resulted from aberrant histone methylation which has been reported to be closely related to incidence and development of tumors. 24 Previous studies have shown that histone methylation was aberrant in ALL, 25 and this phenomenon was correlated with poor prognosis. 26,27 JARID1B is a special demethylase of histone H3K4me2 and H3K4me3.…”

Section: Discussionmentioning

confidence: 98%

“…ALL is a heterogeneous disease with various epigenetic modifications besides cytogenetic changes. Dysregulation of cytogenes resulted from aberrant histone methylation which has been reported to be closely related to incidence and development of tumors . Previous studies have shown that histone methylation was aberrant in ALL, and this phenomenon was correlated with poor prognosis .…”

Section: Discussionmentioning

confidence: 99%

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MiR‐137 inhibits cell proliferation in acute lymphoblastic leukemia by targeting JARID1B

Huang

Zou

Zheng

et al. 2019

European J of Haematology

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Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myelogenous leukemia; CML, chronic myelogenous leukemia; DMSO, dimethyl sulfoxide; H3K4, histone H3 lysine 4;H3K4me2, di-methylation of histone H3 at lysine 4; H3K4me3, tri-methylation of histone H3 at lysine 4; miRNAs, MicroRNAs; MTT, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-Htetrazolium bromide; qRT-PCR, real-time polymerase chain reaction. AbstractAim: This study aimed to investigate the possible functions of interaction between JARID1B and miR-137 in ALL. Methods: The levels of H3K4me3 and H3K4me2 and the expression of JARID1Band miR-137 were analyzed in six ALL cell lines and 30 ALL patients. The effects of miR-137 and JARID1B on cell proliferation and apoptosis were investigated by silencing or promoting the respective genes. The interaction between miR-137 and JARID1B was confirmed by double-luciferase report assay. Results:The histone H3K4 expressions and miR-137 expression were lower in 30 ALL patients and in six ALL cell lines, while the expression of JARID1B was elevated. A negative correlation was observed between JARID1B and miR-137. Over-expression of miR-137 led to decreasing cell proliferation and increasing apoptosis in MOLT-4 and BALL-1 cells. MiR-137 inhibitor up-regulated JARID1B in these two cell lines, while promoted proliferation in BALL-1 cells only. Dual-luciferase report assay suggested that JARID1B was a direct target of miR-137 in ALL cell lines. Conclusions:The expression of miR-137 was declined in ALL, and JARID1B was directly repressed by miR-137. Aberrant JARID1B expression could result in abnormal histone methylation, which might be one cause of ALL. K E Y W O R D Sadult acute lymphoblastic leukemia, lymphoblastic leukemia, MiR-137

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