Identification of phase II in vivo metabolites of alkyl-anthracenes in rainbow trout (Oncorhynchus mykiss)

Turcotte, Dominique; Headley, John V.; Abudulai, Laila N.; Hodson, Peter V.; Brown, R. Stephen

doi:10.1016/j.chemosphere.2011.08.005

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…However, no information about potential degradation products is obtained in the current study. From previous studies, it is known that metabolic products predominantly produced may be dependent upon both PAH structure and species [58–61]. Future studies should focus on confirming the metabolism potential of fish ELS, as well as identifying the metabolites of alkyl and parent PAHs formed in embryos and larvae of different species.…”

Section: Discussionmentioning

confidence: 97%

Oil droplet fouling and differential toxicokinetics of polycyclic aromatic hydrocarbons in embryos of Atlantic haddock and cod

et al. 2017

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The impact of crude oil pollution on early life stages (ELS) of fish, including larvae and embryos, has received considerable attention in recent years. Of the organic components present in crude oil, polycyclic aromatic hydrocarbons (PAHs) are considered the main class of compounds responsible for toxic effects in marine organisms. Although evidence suggests that they are more toxic, alkylated PAHs remain much less studied than their unsubstituted congeners. Recently, it was established that embryos of Atlantic haddock (Melanogrammus aeglefinus) are particularly sensitive to dispersed crude oil, and it was hypothesized that this was caused by direct interaction with crude oil droplets, which adhered to the chorion of exposed embryos. Such a phenomenon would increase the potential for uptake of less water-soluble compounds, including alkylated PAHs. In the current study, we compared the uptake of parent and alkylated PAHs in Atlantic cod (Gadus morhua) and haddock embryos exposed to dispersed crude oil at a range of environmentally relevant concentrations (10–600 μg oil/liter seawater). Although the species are biologically very similar, the cod chorion does not become fouled with oil droplets, even when the two species are exposed to dispersions of crude oil droplets under similar conditions. A close correlation between the degree of fouling and toxicological response (heart defects, craniofacial malformation) was observed. Oil droplet fouling in haddock led to both quantitative and qualitative differences in PAH uptake. Finally, kinetic data on a large suite of PAHs showed differential elimination, suggesting differential metabolism of unsubstituted versus alkylated compounds.

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Section: Discussionmentioning

confidence: 97%

Oil droplet fouling and differential toxicokinetics of polycyclic aromatic hydrocarbons in embryos of Atlantic haddock and cod

et al. 2017

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“…[2,3] It is well established that alkylated homologues of certain PAHs (known as alkylated PAHs) can be present in high abundance in environmental samples, and, in some cases, can be more toxic than their parent PAHs. [4,5] In addition, certain groups of alkylated PAHs in crude oil released into the marine environment (e.g., alkylated chrysenes) are highly resistant to natural weathering processes such as volatilization, photooxidation, and biodegradation. [6][7][8] Furthermore, due to their low aqueous solubility, the relative concentrations of some of these PAHs can increase over time under certain environmental conditions.…”

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confidence: 99%

“…They are also formed during the incomplete combustion of coal, oil, gas, or other organic substances . It is well established that alkylated homologues of certain PAHs (known as alkylated PAHs) can be present in high abundance in environmental samples, and, in some cases, can be more toxic than their parent PAHs . In addition, certain groups of alkylated PAHs in crude oil released into the marine environment (e.g., alkylated chrysenes) are highly resistant to natural weathering processes such as volatilization, photooxidation, and biodegradation .…”

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Development and application of an analytical method using gas chromatography/triple quadrupole mass spectrometry for characterizing alkylated chrysenes in crude oil samples

John

Yin

Mulabagal

et al. 2014

Rapid Comm Mass Spectrometry

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Spilled Oil Composition and the Natural Carbon Cycle: The True Drivers of Environmental Fate and Effects of Oil Spills

Overton

Wetzel

Wickliffe

et al. 2019

Scenarios and Responses to Future Deep Oil Spills

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Identification of phase II in vivo metabolites of alkyl-anthracenes in rainbow trout (Oncorhynchus mykiss)

Cited by 6 publications

References 29 publications

Oil droplet fouling and differential toxicokinetics of polycyclic aromatic hydrocarbons in embryos of Atlantic haddock and cod

Oil droplet fouling and differential toxicokinetics of polycyclic aromatic hydrocarbons in embryos of Atlantic haddock and cod

Development and application of an analytical method using gas chromatography/triple quadrupole mass spectrometry for characterizing alkylated chrysenes in crude oil samples

Spilled Oil Composition and the Natural Carbon Cycle: The True Drivers of Environmental Fate and Effects of Oil Spills

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