Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

Biesiada, Lidia; Sakowicz, Agata; Grzesiak, Mariusz; Borowiec, Maciej; Lisowska, M; Pietrucha, Tadeusz; Kaisenberg, Constantin von; Lewandowski, Krzysztof C.

doi:10.1007/s00439-019-02016-6

Cited by 6 publications

(4 citation statements)

References 57 publications

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“…Another example of a gene where differentially expressed transcripts can be identified in disease is the one coding for leptin (LEP). As expected, LEP was highly upregulated at the gene level in disease compared to control, confirming numerous previous observations, including from our group (Madeleneau et al 2015 ; Biesiada et al 2019 ). The alternative splicing profile of LEP showed that the first part of the gene (exons 1–2a) has a higher expression in diseased placentas as compared to controls.…”

Section: Discussionsupporting

confidence: 92%

Alternative splicing in normal and pathological human placentas is correlated to genetic variants

et al. 2021

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Two major obstetric diseases, preeclampsia (PE), a pregnancy-induced endothelial dysfunction leading to hypertension and proteinuria, and intra-uterine growth-restriction (IUGR), a failure of the fetus to acquire its normal growth, are generally triggered by placental dysfunction. Many studies have evaluated gene expression deregulations in these diseases, but none has tackled systematically the role of alternative splicing. In the present study, we show that alternative splicing is an essential feature of placental diseases, affecting 1060 and 1409 genes in PE vs controls and IUGR vs controls, respectively, many of those involved in placental function. While in IUGR placentas, alternative splicing affects genes specifically related to pregnancy, in preeclamptic placentas, it impacts a mix of genes related to pregnancy and brain diseases. Also, alternative splicing variations can be detected at the individual level as sharp splicing differences between different placentas. We correlate these variations with genetic variants to define splicing Quantitative Trait Loci (sQTL) in the subset of the 48 genes the most strongly alternatively spliced in placental diseases. We show that alternative splicing is at least partly piloted by genetic variants located either in cis (52 QTL identified) or in trans (52 QTL identified). In particular, we found four chromosomal regions that impact the splicing of genes in the placenta. The present work provides a new vision of placental gene expression regulation that warrants further studies.

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Section: Discussionsupporting

confidence: 92%

Alternative splicing in normal and pathological human placentas is correlated to genetic variants

et al. 2021

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“…Among them, F13A1 is related to the heat stress tolerance of pregnant ewes 68 , ARNTL indirectly affects the fertility of animals by affecting the circadian rhythm of the animal’s ability 69 , 70 . DNMBP has a role in membrane transport between the cell surface and the Golgi apparatus (through genetic similarity), and GLIS3 affects the development of organs, such as the fetal pancreas or thyroid 71 – 73 .…”

Section: Resultsmentioning

confidence: 99%

“…F13A1 improves heat stress tolerance of ewes 68 , while UQCRH protects the organisms from radiation-induced ovarian damage 67 , which is essential for sheep living in desert environments. As for CCDC178 and CNGA1, they are involved in immune repair 77 , 78 , while GLIS3 71 – 73 and GNAQ 76 are involved in stable fetal organ development. EEPD1 56 plays a role in maintaining the stability of embryonic genome replication.…”

Section: Discussionmentioning

confidence: 99%

Analysis on the desert adaptability of indigenous sheep in the southern edge of Taklimakan Desert

Chenglong

Liu

Zhang

et al. 2022

Sci Rep

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The southern margin of the Taklimakan Desert is characterized by low rainfall, heavy sandstorms, sparse vegetation and harsh ecological environment. The indigenous sheep in this area are rich in resources, with the advantages of perennial estrus and good resistance to stress in most sheep. Exploring the molecular markers of livestock adaptability in this environment will provide the molecular basis for breeding research to cope with extreme future changes in the desert environment. In this study, we analyzed the population genetic structure and linkage imbalance of five sheep breeds with three different agricultural geographic characteristics using four complementary genomic selection signals: fixation index (FST), cross-population extended haplotype homozygosity (xp-EHH), Rsb (extended haplotype homozygosity between-populations) and iHS (integrated haplotype homozygosity score). We used Illumina Ovine SNP 50K Genotyping BeadChip Array, and gene annotation and enrichment analysis were performed on selected regions of the obtained genome. The ovary of Qira Black sheep (Follicular phase, Luteal phase, 30th day of pregnancy, 45th day of pregnancy) was collected, and the differentially expressed genes were screened by transcriptomic sequencing. Genome-wide selective sweep results and transcriptome data were combined for association analysis to obtain candidate genes associated with perennial estrus and stable reproduction. In order to verify the significance of the results, 15 resulting genes were randomly selected for fluorescence quantitative analysis. The results showed that Dolang sheep and Qira Black sheep evolved from Kazak sheep. Linkage disequilibrium analysis showed that the decay rate of sheep breeds in the Taklimakan Desert was higher than that in Yili grassland. The signals of FST, xp-EHH, Rsb and iHS detected 526, 332, 308 and 408 genes, respectively, under the threshold of 1% and 17 overlapping genes under the threshold of 5%. A total of 29 genes were detected in association analysis of whole-genome and transcriptome data. This study reveals the genetic mechanism of perennial estrus and environmental adaptability of indigenous sheep breeds in the Taklimakan Desert. It provides a theoretical basis for the conservation and exploitation of genetic resources of indigenous sheep breeds in extreme desert environment. This provides a new perspective for the quick adaptation of sheep and other mammals to extreme environments and future climate changes.

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“…Intrauterine growth restriction (IUGR) is a common pregnancy complication associated with significant adverse perinatal outcomes 1 . It is an important cause of perinatal morbidity and death, 2 affecting 10%–15% of pregnant women worldwide 3 . IUGR is closely related to malnutrition during pregnancy, infectious diseases, pregnancy‐induced hypertension, substance abuse, and teratogen exposures, 1 among which malnutrition during pregnancy is the most common cause of IUGR 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Effect of electro‐acupuncture at ST 36 on maternal food restriction‐induced lung phenotype in rat offspring

Mou

Jiang

Zhao

et al. 2021

Pediatric Pulmonology

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Maternal food restriction (MFR) during pregnancy leads to pulmonary dysplasia in the newborn period and increases susceptibility to diseases, such as asthma and chronic lung disease, later in life. Previous studies have shown that maternal electro-acupuncture (EA) applied to "Zusanli" (ST 36) could prevent the abnormal expression of key lung developmental signaling pathways and improve the lung morphology and function in perinatal nicotine exposed offspring. There is a significant overlap in lung developmental signaling pathways affected by perinatal nicotine exposure and MFR during pregnancy; however, whether maternal EA at ST 36 also blocks the MFR-induced lung phenotype is unknown. Here, we examined the effects of EA applied to maternal ST 36 on lung morphology and function and the expression of key lung developmental signaling pathways, and the hypercorticoid state associated with MFR during pregnancy. These effects were compared with those of metyrapone, an intervention known to block MFR-induced offspring hypercorticoid state and the resultant pulmonary pathology. Like metyrapone, maternal EA at ST 36 blocked the MFR-induced changes in key developmental signaling pathways and protected the MFR-induced changes in lung morphology and function. These results offer a novel and safe, nonpharmacologic approach to prevent MFR-induced pulmonary dysplasia in offspring.

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Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study

Cited by 6 publications

References 57 publications

Alternative splicing in normal and pathological human placentas is correlated to genetic variants

Alternative splicing in normal and pathological human placentas is correlated to genetic variants

Analysis on the desert adaptability of indigenous sheep in the southern edge of Taklimakan Desert

Effect of electro‐acupuncture at ST 36 on maternal food restriction‐induced lung phenotype in rat offspring

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