Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

Guo, Naici; Minas, Giorgos; Synowsky, Silvia; Dunne, Margaret R.; Ahmed, Hasnain; McShane, Rhiannon; Bhardwaj, Anshul; Donlon, Noel E; Lorton, Cliona; O’Sullivan, Jacintha; Reynolds, John V.; Caie, Peter D.; Shirran, Sally L.; Lynch, Andy G.; Stewart, Alan J.; Arya, Swati

doi:10.1016/j.jprot.2022.104684

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2024

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“…Differential plasma protein detection is considered a suitable approach for predicting NACT response in esophageal cancer and nasopharyngeal carcinoma [ 16 , 17 ]. This study indicated significant differences in plasma protein profiles between NACT-resistant and NACT-sensitive patients with AGC, suggesting that differential plasma protein detection may be a feasible method for predicting NACT response in AGC.…”

Section: Discussionmentioning

confidence: 99%

“…The detection of proteomic biomarkers can be achieved through either tissue biopsy or liquid biopsy, with the latter offering advantages in terms of minimally invasive and convenient sampling [ 13 , 14 ]. Plasma proteins were the most common biomarkers of liquid biopsy and a series of differential plasma protein profiles related to chemotherapy effectiveness were performed in ovarian cancer [ 15 ], esophageal cancer [ 16 ], and locally advanced nasopharyngeal carcinoma [ 17 ]. However, a comprehensive screening of plasma proteins associated with NACT in AGC has not been systematically conducted.…”

Section: Introductionmentioning

confidence: 99%

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