2024
DOI: 10.1101/2024.03.15.24304200
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Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities

Douglas P. Loesch,
Manik Garg,
Dorota Matelska
et al.

Abstract: Introduction: Type 2 diabetes (T2D) is a heterogeneous disorder for which disease-causing pathways are incompletely understood. Here, we mapped genetic risk for T2D and its comorbidities to proteins, mechanistic pathways and clinical outcomes using proteogenomic data from a population-scale biobank and two randomized controlled trials. Methods: We tested polygenic scores (PGS) for T2D and its cardiometabolic comorbidities, plus five partitioned T2D PGS (beta cell, lipodystrophy, liver lipid, obesity, and liver… Show more

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