Identification of plastic additives: Py/TD-GC-HRMS method development and application on food containers

Akoueson, Fleurine; Chbib, Chaza; Brémard, Armance; Monchy, Sébastien; Paul-Pont, Ika; Doyen, Périne; Dehaut, Alexandre; Duflos, Guillaume

doi:10.1016/j.jaap.2022.105745

Cited by 13 publications

(3 citation statements)

References 51 publications

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“…TD-GC–MS has been found to be effective for the quantification of brominated flame retardants (especially for BDE-209) in curtains and car interiors (Shin and Baek 2012 ); meanwhile, Py-GC–MS has been increasingly used for the detection of PAEs, flame retardants, ultraviolet stabilizers, and bisphenols. (Akoueson et al 2022 ; Deng et al 2022 ).…”

Section: Analytical Methods For Additives On (Microplastic) Fibersmentioning

confidence: 99%

An Overview of Chemical Additives on (Micro)Plastic Fibers: Occurrence, Release, and Health Risks

Chen

Zhang

et al. 2022

Reviews Env.Contamination (formerly:Residue Reviews)

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Plastic fibers are ubiquitous in daily life with additives incorporated to improve their performance. Only a few restrictions exist for a paucity of common additives, while most of the additives used in textile industry have not been clearly regulated with threshold limits. The production of synthetic fibers, which can shed fibrous microplastics easily (< 5 mm) through mechanical abrasion and weathering, is increasing annually. These fibrous microplastics have become the main composition of microplastics in the environment. This review focuses on additives on synthetic fibers; we summarized the detection methods of additives, compared concentrations of different additive types (plasticizers, flame retardants, antioxidants, and surfactants) on (micro)plastic fibers, and analyzed their release and exposure pathways to environment and human beings. Our prediction shows that the amounts of predominant additives (phthalates, organophosphate esters, bisphenols, per- and polyfluoroalkyl substances, and nonylphenol ethoxylates) released from clothing microplastic fibers (MFs) are estimated to reach 35, 10, 553, 0.4, and 568 ton/year to water worldwide, respectively; and 119, 35, 1911, 1.4, and 1965 ton/year to air, respectively. Human exposure to MF additives via inhalation is estimated to be up to 4.5–6440 µg/person annually for the above five additives, and via ingestion 0.1–204 µg/person. Notably, the release of additives from face masks is nonnegligible that annual human exposure to phthalates, organophosphate esters, per- and polyfluoroalkyl substances from masks via inhalation is approximately 491–1820 µg/person. This review helps understand the environmental fate and potential risks of released additives from (micro)plastic fibers, with a view to providing a basis for future research and policy designation of textile additives. Graphical Abstract

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Section: Analytical Methods For Additives On (Microplastic) Fibersmentioning

confidence: 99%

An Overview of Chemical Additives on (Micro)Plastic Fibers: Occurrence, Release, and Health Risks

Chen

Zhang

et al. 2022

Reviews Env.Contamination (formerly:Residue Reviews)

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“…All these will not change fundamentally unless market needs, industrial chain, and governmental policy experience synergistic changes, where green chemistry technologies may provide a solution. − To facilitate effective systems thinking , and innovative policy-making, timely toxicant identification and health effect assessment at the front end are key . The coming-of-age HRMS techniques and merged workflows will be crucial drivers in this, with demonstrated successes in suspect screening and NTA of ubiquitous complex mixtures such as PFAS ,, and plastics additives (using pyrolysis-GC-HRMS). − Studies are underway in targeting the internal component of the chemical exposome to uncover new chemical space that humans are critically exposed to. ,, …”

Section: Toward Merging Targeted and Non-targeted Approachesmentioning

confidence: 99%

“… 281 The coming-of-age HRMS techniques and merged workflows will be crucial drivers in this, with demonstrated successes in suspect screening and NTA of ubiquitous complex mixtures such as PFAS 266 , 282 , 283 and plastics additives (using pyrolysis-GC-HRMS). 284 − 286 Studies are underway in targeting the internal component of the chemical exposome to uncover new chemical space that humans are critically exposed to. 46 , 287 , 288 …”

Section: Toward Merging Targeted and Non-targeted Approachesmentioning

confidence: 99%

High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage

Lai,

Koelmel,

Walker

et al. 2024

Environ. Sci. Technol.

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In the modern "omics" era, measurement of the human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics and metabolomics, has emerged as a leading technology to broadly profile chemical exposure agents and related biomolecules for accurate mass measurement, high sensitivity, rapid data acquisition, and increased resolution of chemical space. Non-targeted approaches are increasingly accessible, supporting a shift from conventional hypothesis-driven, quantitation-centric targeted analyses toward data-driven, hypothesisgenerating chemical exposome-wide profiling. However, HRMS-based exposomics encounters unique challenges. New analytical and computational infrastructures are needed to expand the analysis coverage through streamlined, scalable, and harmonized workflows and data pipelines that permit longitudinal chemical exposome tracking, retrospective validation, and multi-omics integration for meaningful health-oriented inferences. In this article, we survey the literature on state-of-the-art HRMS-based technologies, review current analytical workflows and informatic pipelines, and provide an up-to-date reference on exposomic approaches for chemists, toxicologists, epidemiologists, care providers, and stakeholders in health sciences and medicine. We propose efforts to benchmark fit-for-purpose platforms for expanding coverage of chemical space, including gas/liquid chromatography−HRMS (GC-HRMS and LC-HRMS), and discuss opportunities, challenges, and strategies to advance the burgeoning field of the exposome.

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Shortening the Analysis Time of a “Ready-To-Use” Relative Response Factor Database-Coupled Pyrolyzer/Thermal Desorption–Gas Chromatography–Mass Spectrometry Method of Screening for Phthalate Esters, Polybrominated Diphenyl Ethers, and Polybrominated Biphenyls in Polymers

Kudo,

Uchimura

2024

Chromatographia

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Identification of plastic additives: Py/TD-GC-HRMS method development and application on food containers

Cited by 13 publications

References 51 publications

An Overview of Chemical Additives on (Micro)Plastic Fibers: Occurrence, Release, and Health Risks

An Overview of Chemical Additives on (Micro)Plastic Fibers: Occurrence, Release, and Health Risks

High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage

Shortening the Analysis Time of a “Ready-To-Use” Relative Response Factor Database-Coupled Pyrolyzer/Thermal Desorption–Gas Chromatography–Mass Spectrometry Method of Screening for Phthalate Esters, Polybrominated Diphenyl Ethers, and Polybrominated Biphenyls in Polymers

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