2016
DOI: 10.1017/s1751731115002761
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Identification of pleiotropic genes and gene sets underlying growth and immunity traits: a case study on Meishan pigs

Abstract: Both growth and immune capacity are important traits in animal breeding. The animal quantitative trait loci (QTL) database is a valuable resource and can be used for interpreting the genetic mechanisms that underlie growth and immune traits. However, QTL intervals often involve too many candidate genes to find the true causal genes. Therefore, the aim of this study was to provide an effective annotation pipeline that can make full use of the information of Gene Ontology terms annotation, linkage gene blocks an… Show more

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Cited by 14 publications
(10 citation statements)
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“…A total of 47 samples from PW animals were sequenced in the present study, and the sequenced individuals from Taihu (n = 252) and western populations (n = 120) were obtained from previous studies (Wang et al, 2015;Zhang et al, 2016). All individuals were genotyped using the GGRS protocol (http://klab.sjtu.edu.cn/GGRS/) (Chen et al, 2013).…”
Section: Animals and Genotypingmentioning
confidence: 99%
“…A total of 47 samples from PW animals were sequenced in the present study, and the sequenced individuals from Taihu (n = 252) and western populations (n = 120) were obtained from previous studies (Wang et al, 2015;Zhang et al, 2016). All individuals were genotyped using the GGRS protocol (http://klab.sjtu.edu.cn/GGRS/) (Chen et al, 2013).…”
Section: Animals and Genotypingmentioning
confidence: 99%
“…Moreover, the genes containing indels were associated with the PI3K‐Akt signalling pathway, which is reportedly associated with traits of immunity and growth (Table S3) (Zhang et al . 2016), indicating that these indels may be associated with these two traits.…”
mentioning
confidence: 99%
“…The ACVRL1 gene is a TGFb/BMP type I receptor that plays a key role in the regulation of endothelial cell proliferation and maintenance of vascular integrity ( Tual-Chalot et al, 2014 ), while ACVR1B acts in a paracrine manner on skin epithelial cells to suppress tumorigenesis ( Qiu et al, 2011 ). These two genes also play essential roles in bone growth and morphogenesis ( Merino et al, 1999 ), suggesting a pleiotropic SNP in the haplotype block region harboring these genes ( Solovieff et al, 2013 ; Zhang et al, 2016 ). Furthermore, GGT5 has been found to code for a cell surface protein that helps in the hydrolysis of the gamma-glutamyl bond of glutathione and glutathione S -conjugates ( Wickham et al, 2011 ).…”
Section: Discussionmentioning
confidence: 99%