Identification of polyphenolic contents, <i>in vitro</i> evaluation of antioxidant and antidiabetic potentials of a polyherbal formulation-Mehani

Venkateswaran, Meenakshi; Jayabal, Sasidharan; Murugesan, Selvakumar; Periyasamy, Sureshkumar

doi:10.1080/14786419.2019.1660978

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…Now-a-days, researchers are focused on the development of antiviral bioactive compounds from medicinal plants with high curative effect and no toxicity [ 8 , 9 ]. Medicinal plant-based bioactives have been traditionally used to treat many infectious and respiratory diseases [ 10 , 11 ]. In earlier reports, numerous computational screening studies have mapped out the potential bioactives from medicinal plants against the targets of SARS-CoV-2 [ [12] , [13] , [14] ].…”

Section: Introductionmentioning

confidence: 99%

Targeting COVID-19 (SARS-CoV-2) main protease through active phytocompounds of ayurvedic medicinal plants – Emblica officinalis (Amla), Phyllanthus niruri Linn. (Bhumi Amla) and Tinospora cordifolia (Giloy) – A molecular docking and simulation study

Murugesan

Kottekad

Crasta

et al. 2021

Computers in Biology and Medicine

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Coronavirus Disease-2019 (COVID-19), a viral disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a global pandemic by WHO in 2020. In this scenario, SARS-CoV-2 main protease (COVID-19 M pro ), an enzyme mainly involved in viral replication and transcription is identified as a crucial target for drug discovery. Traditionally used medicinal plants contain a large amount of bioactives and pave a new path to develop drugs and medications for COVID-19. The present study was aimed to examine the potential of Emblica officinalis (amla), Phyllanthus niruri Linn. (bhumi amla) and Tinospora cordifolia (giloy) bioactive compounds to inhibit the enzymatic activity of COVID-19 M pro . In total, 96 bioactive compounds were selected and docked with COVID-19 M pro and further validated by molecular dynamics study. From the docking and molecular dynamics study, it was revealed that the bioactives namely amritoside, apigenin-6-C-glucosyl7-O-glucoside, pectolinarin and astragalin showed better binding affinities with COVID-19 M pro . Drug-likeness, ADEMT and bioactivity score prediction of best drug candidates were evaluated by DruLiTo, pkCSM and Molinspiration servers, respectively. Overall, the in silico results confirmed that the validated bioactives could be exploited as promising COVID-19 M pro inhibitors.

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Section: Introductionmentioning

confidence: 99%

Targeting COVID-19 (SARS-CoV-2) main protease through active phytocompounds of ayurvedic medicinal plants – Emblica officinalis (Amla), Phyllanthus niruri Linn. (Bhumi Amla) and Tinospora cordifolia (Giloy) – A molecular docking and simulation study

Murugesan

Kottekad

Crasta

et al. 2021

Computers in Biology and Medicine

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“…The colour of DPPH turns from purple to yellow and gets converted into 1,1-diphenyl-2-picrylhydrazine with a decrease in absorbance at 517 nm after reduction by ZnO NS's indicates the scavenging potentials of the NPs. The slow color change of DPPH solution from purple to pale yellow in the presence of ZnO NSs is due to shifting of electron density present at oxygen atom to the odd electron present at nitrogen atom in DPPH [73]. Antioxidant activity of ower like ZnO NSs was found (Figure.9) to increase with the increase in concentration in a dosedependent manner from 12.5 µg/mlto 1000 µg/ml.…”

Section: Antioxidant Activitymentioning

confidence: 90%

Green and sustainable preparation of flower-like ZnO nanostructures via soft bio-template approach for the enhancement of biomedical applications

Senthilkumar¹,

Nandhakumar

Priya

et al. 2021

Appl. Phys. A

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Investigation onthe biomedical applications of ower like Zinc Oxide (ZnO) nanostructures (NSs)synthesized by using aqueous extract of Oryza punctata (red rice) is reported for the rst time. For the sustainable preparation of ZnO NSs, the precursors zinc nitrate and the rice extract act as the biotemplate material. The powder X-ray diffraction analysis demonstrates the crystallographic structure and purity of the bio-prepared ZnO NSs. Fourier transform infrared spectral studies exhibits the existence of several functional groups in the rice extract and synthesized ZnO NSs. The FT-Raman spectroscopy analysis used to detect the presence of the defects in the synthesized material. The UV absorption onset shows the peaks at 270 nm & 370 nm for rice extract and ZnO NSs, respectively. The optimal energy bandgap value for the ZnO NSs was found to be 3.29 eV. The zinc oxygen vacancies, zinc interstitial and surface defects were determined by photoluminescence spectroscopy. The dynamic light scattering analysis reveals the material stability and average particle size distribution of the prepared ZnO NSs. The ower like morphology of the ZnO NSs was con rmed by eld emission scanning electron microscopy analysis. ZnO NSs were tested for cytotoxicity activity against MCF-7 cell line and antibacterial properties using two gram positive (Staphylococcus Aureus, Bacillus Subtilis) and two gram negative bacteria (Salmonella Paratyphi, Escherichia Coli). Signi cant antioxidant activity was studied by the bioprepared ZnO NSs against scavenging of DPPH (di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium) free radicals. The ower like ZnO NSs showed a signi cant anti-arthritic activity which exhibited a maximum inhibition of protein denaturation (78.94±1.62 %) and membrane protective activity (81.12±1.25 %) at a dose of 0.5mg/mL concentration.

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“…Supernatant was collected and the residue was again extracted with aqueous methanolic extract for 24 hr. The collected supernatants were fractionated using ethyl acetate, concentrated in rotary vacuum evaporator and stored at −20°C for further studies (Venkateswaran et al., 2019; Yang et al, 2009).…”

Section: Methodsmentioning

confidence: 99%

Polyphenol‐rich Indian ginger cultivars ameliorate GLUT4 activity in C2C12 cells, inhibit diabetes‐related enzymes and LPS‐induced inflammation: An in vitro study

et al. 2021

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Diabetes is a chronic metabolic disorder that results in distorted insulin signaling and microvascular complications. Current antidiabetic drugs possess harmful long term side effects, necessitating the need for alternate or compliment therapy with lesser issues. Medicinal plants such as ginger have been reported to possess several beneficial activities including antidiabetic activity. The antidiabetic efficacy of microwave-assisted polyphenolic extracts of Indian ginger cultivars from Odisha (MPO) and Tamil Nadu (MPT) is reported here. MPT and MPO showed insulin stimulated glucose uptake of 1.74 ± 0.25 and 1.47 ± 0.15 fold at 6.25 µg/ml of concentrations in C2C12 cells respectively when compared to control. MPT possessed α-amylase, α-glucosidase inhibitory and anti-glycation properties. It also showed DPPH radical scavenging activity (7.69 ± 0.001%), inhibited LPS-induced nitric oxide production (1.06 ± 0.004 fold) than the latter and increased the GLUT4 protein expression by 1.4 fold. Major active compounds such as shogaol and gingerol derivatives, curcumene, zingiberone were identified through GC-ESI/MS analysis and D-pinitol (cyclitol) was identified through HPLC analysis in this variety. This is the first paper to report the presence of an antidiabetic compound, D-pinitol, in the ginger variety. Polyphenol rich, biologically potent ginger extracts can be a good food and nutraceutical supplement to address diabetes and related complications. Practical applications Ginger is a native spice of South Asian Countries including India. Ginger extracts possess several medicinal properties such as anti-inflammatory, antidiabetic and antioxidant activities. It is used to treat nausea, vomiting and commonly used as a food flavouring agent and dietary food supplement. Our study shows the antidiabetic, anti-glycation and antioxidant efficacy of polyphenol rich Indian ginger cultivars grown in different geographical regions. Variations in the biological activities between the MPT and MPO ginger variety was observed. Different environmental conditions and their corresponding metabolite accumulation can be correlated with

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Identification of polyphenolic contents, in vitro evaluation of antioxidant and antidiabetic potentials of a polyherbal formulation-Mehani

Cited by 10 publications

References 19 publications

Targeting COVID-19 (SARS-CoV-2) main protease through active phytocompounds of ayurvedic medicinal plants – Emblica officinalis (Amla), Phyllanthus niruri Linn. (Bhumi Amla) and Tinospora cordifolia (Giloy) – A molecular docking and simulation study

Targeting COVID-19 (SARS-CoV-2) main protease through active phytocompounds of ayurvedic medicinal plants – Emblica officinalis (Amla), Phyllanthus niruri Linn. (Bhumi Amla) and Tinospora cordifolia (Giloy) – A molecular docking and simulation study

Green and sustainable preparation of flower-like ZnO nanostructures via soft bio-template approach for the enhancement of biomedical applications

Polyphenol‐rich Indian ginger cultivars ameliorate GLUT4 activity in C2C12 cells, inhibit diabetes‐related enzymes and LPS‐induced inflammation: An in vitro study

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