2010
DOI: 10.1016/j.tox.2010.05.004
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Identification of potential biomarkers from gene expression profiles in rat lungs intratracheally instilled with C60 fullerenes

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Cited by 23 publications
(19 citation statements)
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“…Gene expression analysis is expected to elucidate the toxicological effects of nanomaterials relevant to specific histopathological phenotypes. We have previously analyzed gene expression profiles in rat lungs after intratracheal instillation of C 60 fullerenes (Fujita et al., 2009a , 2010 ). The gene expression profiles demonstrated marked correspondence with results from other conventional methods such as immunohistochemical and BALF cell analysis.…”
Section: Introductionmentioning
confidence: 99%
“…Gene expression analysis is expected to elucidate the toxicological effects of nanomaterials relevant to specific histopathological phenotypes. We have previously analyzed gene expression profiles in rat lungs after intratracheal instillation of C 60 fullerenes (Fujita et al., 2009a , 2010 ). The gene expression profiles demonstrated marked correspondence with results from other conventional methods such as immunohistochemical and BALF cell analysis.…”
Section: Introductionmentioning
confidence: 99%
“…Pendrin up-regulation is seen in: 1) airway epithelial cultures chronically exposed to cytokines, including IL-4, IL-13, and IL-17A; 2) rodent models of inflammatory lung disease, including allergen (ovalbumin)-induced asthma, chronic obstructive pulmonary disease, infection, and industrial toxin exposure; and 3) humans with rhinovirus infection, asthma, cystic fibrosis (CF), rhinitis, and chronic rhinosinusitis (10,11,(17)(18)(19)(20)(21)(22)(23)(24)(25). Pendrin knockout is also associated with reduced lung inflammation in a murine model of Bordetella pertussis lung infection (26).…”
mentioning
confidence: 99%
“…Intermediary organic solvents are often used and subsequently removed by evaporation; 6 (c) encapsulation of C 60 with carriers, such as g-cyclodextrine (g-CD) 7 and surfactants. 8 The latter two methods are relatively effective. However, the residual toxic organic solventsor the coexistent carriers in the C 60 aqueous solution often result in negative effects on the biological activities of C 60 .…”
mentioning
confidence: 99%