Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors

Rodrigues, Robim Marcelino; Sachinidis, Agapios; Boe, Veerle De; Rogiers, Vera; Vanhaecke, Tamara; Kock, Joery De

doi:10.1016/j.tiv.2014.10.012

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…TOC i − TOC o TOC i (7) where TOC i and TOC o represent the TOC at the beginning and the end of each experimental run, respectively.…”

Section: % Mineralization =mentioning

confidence: 99%

Photocatalytic degradation of commercial acetaminophen: evaluation, modeling, and scaling-up of photoreactors

Castilla-Caballero¹,

Machuca-Martínez²,

Bustillo-Lecompte³

et al. 2024

Preprint

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In this work, the performance of a pilot-scale solar CPC reactor was evaluated for the degradation of commercial acetaminophen, using TiO2 P25 as a catalyst. The statistical Taguchi’s method was used to estimate the combination of initial pH and catalyst load while tackling the variability of the solar radiation intensity under tropical weather conditions through the estimation of the signal-to-noise ratios (S/N) of the controllable variables. Moreover, a kinetic law that included the explicit dependence on the local volumetric rate of photon absorption (LVRPA) was used. The radiant field was estimated by joining the Six Flux Model (SFM) with a solar emission model based on clarity index (KC), whereas the mass balance was coupled to the hydrodynamic equations, corresponding to the turbulent regime. For scaling-up purposes, the ratio of the total area-to-total-pollutant volume (AT/VT) was varied for observing the effect of this parameter on the overall plant performance. The Taguchi’s experimental design results showed that the best combination of initial pH and catalyst load was 9 and 0.6 g L−1, respectively. Also, full-scale plants would require far fewer ratios of AT/VT than for pilot or intermediate-scale ones. This information may be beneficial for reducing assembling costs of photocatalytic reactors scaling-up.

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“…TOC i − TOC o TOC i (7) where TOC i and TOC o represent the TOC at the beginning and the end of each experimental run, respectively.…”

Section: % Mineralization =mentioning

confidence: 99%

Photocatalytic degradation of commercial acetaminophen: evaluation, modeling, and scaling-up of photoreactors

Castilla-Caballero¹,

Machuca-Martínez²,

Bustillo-Lecompte³

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Nonetheless, it is expected that higher concentrations can be found in hospitals wastewaters although there are no reports of these concentrations in literature. Furthermore, water contaminated with pharmaceuticals such as acetaminophen can cause hepatic damage in humans [7,8] and alter the equilibrium of aquatic ecosystems due to its toxicity [9,10]. As a result, there is a need to develop efficient technologies to remove emerging contaminants from industrial wastewater and water bodies.…”

mentioning

confidence: 99%

Photocatalytic Degradation of Commercial Acetaminophen: Evaluation, Modeling, and Scaling-Up of Photoreactors

et al. 2018

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Abstract:In this work, the performance of a pilot-scale solar CPC reactor was evaluated for the degradation of commercial acetaminophen, using TiO 2 P25 as a catalyst. The statistical Taguchi's method was used to estimate the combination of initial pH and catalyst load while tackling the variability of the solar radiation intensity under tropical weather conditions through the estimation of the signal-to-noise ratios (S/N) of the controllable variables. Moreover, a kinetic law that included the explicit dependence on the local volumetric rate of photon absorption (LVRPA) was used. The radiant field was estimated by joining the Six Flux Model (SFM) with a solar emission model based on clarity index (K C ), whereas the mass balance was coupled to the hydrodynamic equations, corresponding to the turbulent regime. For scaling-up purposes, the ratio of the total area-to-total-pollutant volume (A T /V T ) was varied for observing the effect of this parameter on the overall plant performance. The Taguchi's experimental design results showed that the best combination of initial pH and catalyst load was 9 and 0.6 g L −1 , respectively. Also, full-scale plants would require far fewer ratios of A T /V T than for pilot or intermediate-scale ones. This information may be beneficial for reducing assembling costs of photocatalytic reactors scaling-up.

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Mechanisms and in vitro models of drug-induced cholestasis

et al. 2019

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Cholestasis underlies one of the major manifestations of drug-induced liver injury. Drug-induced cholestatic liver toxicity is a complex process, as it can be triggered by a variety of factors that induce 2 types of biological responses, namely a deteriorative response, caused by bile acid accumulation, and an adaptive response, aimed at removing the accumulated bile acids. Several key events in both types of responses have been characterized in the past few years. In parallel, many efforts have focused on the development and further optimization of experimental cell culture models to predict the occurrence of drug-induced cholestatic liver toxicity in vivo. In this paper, a state-of-the-art overview of mechanisms and in vitro models of drug-induced cholestatic liver injury is provided.

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Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors

Cited by 5 publications

References 27 publications

Photocatalytic degradation of commercial acetaminophen: evaluation, modeling, and scaling-up of photoreactors

Photocatalytic degradation of commercial acetaminophen: evaluation, modeling, and scaling-up of photoreactors

Photocatalytic Degradation of Commercial Acetaminophen: Evaluation, Modeling, and Scaling-Up of Photoreactors

Mechanisms and in vitro models of drug-induced cholestasis

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