2021
DOI: 10.3389/fgene.2021.687979
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Identification of Potential Prognostic Biomarkers Associated With Cancerometastasis in Skin Cutaneous Melanoma

Abstract: Skin cutaneous melanoma (SKCM) is a highly aggressive tumor. The mortality and drug resistance among it are high. Thus, exploring predictive biomarkers for prognosis has become a priority. We aimed to find immune cell-based biomarkers for survival prediction. Here 321 genes were differentially expressed in immune-related groups after ESTIMATE analysis and differential analysis. Two hundred nineteen of them were associated with the metastasis of SKCM via weighted gene co-expression network analysis. Twenty-six … Show more

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Cited by 6 publications
(2 citation statements)
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“…In contrast, a positive correlation between immune infiltration and PLA2G2D expression has been identified in cervical cancer [38]. In addition, upregulation of PLA2G2D improves the prognosis of cutaneous melanoma [41], breast cancer [42], and head and neck squamous cell carcinoma [43]. Together with our results, PLA2G2D represents a good chance of acting as a beneficial regulator rather than an immunosuppressive role in OC.…”
Section: Discussionsupporting
confidence: 70%
“…In contrast, a positive correlation between immune infiltration and PLA2G2D expression has been identified in cervical cancer [38]. In addition, upregulation of PLA2G2D improves the prognosis of cutaneous melanoma [41], breast cancer [42], and head and neck squamous cell carcinoma [43]. Together with our results, PLA2G2D represents a good chance of acting as a beneficial regulator rather than an immunosuppressive role in OC.…”
Section: Discussionsupporting
confidence: 70%
“…P2RY10 expression is increased in synovial tissues and peripheral blood in patients with rheumatoid arthritis and coronary artery disease [27], and the LysoPS-P2Y10 axis has been shown to inhibit TNF-α production in mouse microglia and activate eosinophilic degranulation [17]. A previous study demonstrated that P2RY10 was related to the tumor microenvironment and was a crucial prognostic factor in cutaneous melanoma [28]. Another study showed that P2RY10 was an immune/matrix-related gene that predicted the survival rate of patients with renal cell carcinoma [29].…”
Section: Discussionmentioning
confidence: 99%