Identification of predictors for the comprehensive clinical risk and severity of coronary lesions of acute coronary syndrome

Li, Lihui; Sun, Guangfeng; Yu, Jinlong; Shan, Gaojun; Su, Lide; Dong, Guo-Chung

doi:10.3389/fcvm.2023.1046895

Cited by 4 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A major coronary artery with a stenosis of 50% or more was considered to be significant. SYNTAX (SYNergy between PCI with TAXUS and Cardiac Surgery) scores II were calculated for all patients after the angiography procedure 11 . Patients were classified into two groups with a SYNTAX score of ≥23 and a SYNTAX score of <23.…”

Section: Methodsmentioning

confidence: 99%

Role of simple inflammatory parameters in predicting the severity of coronary artery disease

Aydın,

Uyan,

Karadeniz

et al. 2023

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

SUMMARY OBJECTIVE: In our study, we aimed to find simple, useful biomarkers in patients with non-ST elevation myocardial infarction to predict coronary artery severity. METHODS: Between May 2022 and December 2022, patients diagnosed with non-ST elevation myocardial infarction according to the European cardiology guidelines were included in our study. The Synergy between PCI with Taxus and Cardiac Surgery score was calculated to determine the severity of coronary artery disease. These patients were classified into two groups according to Synergy between PCI with Taxus and Cardiac Surgery≥23 and Synergy between PCI with Taxus and Cardiac Surgery<23 scores. Biochemical markers such as platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were studied in blood tests taken before coronary angiography in patients diagnosed with non-ST elevation myocardial infarction according to current guidelines. These two groups were compared in terms of the data obtained. RESULTS: There were 281 patients in group 1 and 67 patients in group 2. There was no significant difference between the two groups in terms of demographic data such as age and gender. Platelet-to-lymphocyte ratio [group 1=125 (26–134) and group 2=156 (73–293); p=0.001] and neutrophil-to-lymphocyte ratio [group 1=2.71 (1.3–30.2) and group 2=3.2 (2.1–32.1); p=0.002] were higher in the group of patients with a Synergy between PCI with Taxus and Cardiac Surgery score of <23, while lymphocyte-to-monocyte ratio [group 1=3.6 (0.56–11) and group 2=3.4 (0.64–5.75); p=0.017] was lower in group 2. CONCLUSION: We observed that elevated platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios showed coronary artery severity. Multivessel disease and chronic total occlusion rates were observed to be higher in patients with high platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios.

show abstract

Section: Methodsmentioning

confidence: 99%

Role of simple inflammatory parameters in predicting the severity of coronary artery disease

Aydın,

Uyan,

Karadeniz

et al. 2023

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

A prediction model of elderly hip fracture mortality including preoperative red cell distribution width constructed based on the random survival forest (RSF) and Cox risk ratio regression

Zhou,

Wang,

Wang

et al. 2023

Osteoporos Int

View full text Add to dashboard Cite

miR-223-5p serves as a diagnostic biomarker for acute coronary syndrome and its predictive value for the clinical outcome after PCI

Zhang,

Yang,

Chen

et al. 2024

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Acute coronary syndrome (ACS) is a serious cardiovascular disease that severely affects the quality of life and longevity of patients. MicroRNAs (miRNAs) play a key role in the progression of ACS with significant clinical value. The aim of this study was to examine the clinical value of miR-223-5p in ACS and on the occurrence of major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI). Methods The plasma expression of miR-223-5p was detected by RT-qPCR. The correlation of miR-223-5p and cTnI or Gensini score was shown by the Pearson method. Risk factors for the development of ACS were analyzed by multivariate logistic regression. The efficacy of miR-223-5p in identifying patients with ACS was shown by ROC curve. The predictive value of miR-223-5p for MACE development in ACS patients within 6 months after PCI was assessed by Kaplan-Meier curve and multivariate Cox regression. Results miR-223-5p levels were markedly elevated in ACS patients. miR-223-5p was found to be positively related to cTnI or Gensini score. miR-223-5p was a risk factor for ACS and significantly identified patients with ACS. MACE was more likely to occur after PCI in patients with high miR-223-5p levels, and miR-223-5p was an independent prognostic indicator of MACE. Conclusions miR-223-5p had diagnostic value for ACS and predicted MACE after PCI. Supplementary Information The online version contains supplementary material available at 10.1186/s12872-024-04088-3.

show abstract

Identification of predictors for the comprehensive clinical risk and severity of coronary lesions of acute coronary syndrome

Cited by 4 publications

References 39 publications

Role of simple inflammatory parameters in predicting the severity of coronary artery disease

Role of simple inflammatory parameters in predicting the severity of coronary artery disease

A prediction model of elderly hip fracture mortality including preoperative red cell distribution width constructed based on the random survival forest (RSF) and Cox risk ratio regression

miR-223-5p serves as a diagnostic biomarker for acute coronary syndrome and its predictive value for the clinical outcome after PCI

Contact Info

Product

Resources

About