2024
DOI: 10.1021/acs.jmedchem.4c01204
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Identification of Psychoplastogenic Tropanes Lacking Muscarinic Activity

Hunter T. Warren,
Winston L. Chow,
Milan Chytil
et al.

Abstract: Tropane-containing small molecules like scopolamine are a promising class of psychoplastogens. However, their potent antagonism of all muscarinic receptor subtypes presents the potential for undesirable anticholinergic side effects. In an effort to decouple their neuroplasticity-promoting effects from their muscarinic activity, we performed phenotypic structure−activity relationship studies across a variety of structurally distinct subclasses of tropanes. We discovered several novel tropanes capable of signifi… Show more

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