Identification of pure subcortical vascular dementia using
            <sup>11</sup>
            C-Pittsburgh compound B

Lee, J.H.; Kim, S.H.; Kim, G.H.; Seo, Sang Won; Park, H.K.; Oh, Seung Jun; Kim, J.S.; Cheong, Hae-Kwan; Na, D.L.

doi:10.1212/wnl.0b013e318221acee

Cited by 174 publications

(189 citation statements)

References 25 publications

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“…As well as being a risk factor for spontaneous intracerebral haemorrhage (Samarasekera et al, 2012), CAA can result in cognitive deficits independently of AD (Arvanitakis et al, 2011;Boyle et al, 2015;Reijmer et al, 2015), although the exact interaction between these two processes remains unclear. Traditionally AD and SVCI have been described as having distinct neuroimaging profiles (Wardlaw et al, 2013b;Greenberg et al, 2014), but clinically differentiating between the two remains difficult, as both the cognitive symptoms and the imaging findings frequently overlap (Lee et al, 2011;Wardlaw et al, 2013a;Wardlaw et al, 2013b;Greenberg et al, 2014;Lee et al, 2014). Given this, identifying new markers that further improve our ability to discriminate between AD and SVCI remains both relevant and important, in particular with regard to recruitment for clinical trials investigating pharmacological interventions (Ahmed et al, 2014;Andrieu et al, 2015).…”

Section: Svci Subcortical Vascular Cognitive Impairment (Svmci and Svad)mentioning

confidence: 99%

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MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

Banerjee

Kim

Fox

et al. 2017

Brain

201

216

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MRI-visible perivascular spaces are a neuroimaging marker of cerebral small vessel disease.Their location may relate to the type of underlying small vessel pathology: those in the white matter centrum semi-ovale have been associated with cerebral amyloid angiopathy, whilst those in the basal ganglia have been associated with deep perforating artery arteriolosclerosis.Since cerebral amyloid angiopathy is an almost invariable pathological finding in Alzheimer's disease, we hypothesized that MRI-visible perivascular spaces in the centrum semi-ovale would be associated with a clinical diagnosis of Alzheimer's disease, whereas those in the basal ganglia would be associated with subcortical vascular cognitive impairment. We also hypothesised that MRI-visible perivascular spaces in the centrum semiovale would be associated with brain amyloid burden, as detected by amyloid-PET using subcortical vascular cognitive impairment n=116) with standardised MRI and PiB-PET imaging were included. MRI-visible perivascular spaces were rated using a validated 4-point visual rating scale, and then categorised by severity ("none/mild", "moderate" or "frequent/severe").

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Section: Svci Subcortical Vascular Cognitive Impairment (Svmci and Svad)mentioning

confidence: 99%

“…Patients were considered PiB-positive if their global PiB retention ratio was over 1.5 from the mean of the normal control (Lee et al, 2011).…”

Section: Participantsmentioning

confidence: 99%

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

Banerjee

Kim

Fox

et al. 2017

Brain

201

216

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“…99m Tc-HMPAO SPECT is useful to differentiate CBD from other alternative diseases, because in CBD significant reduction of radiopharmaceutical uptake is in frontal, parietal, temporal cortices of the more affected side, in the thalamus and in pontocerebellar regions [30][31][32]34]. In vascular dementias, hypoperfusion is confirmed in bilateral thalami, the anterior cingulate gyrus, the temporal gyri, the caudate heads and the left parahippocampal gyrus, suggesting functional disconnection between frontal lobes and subcortical structures [31].…”

Section: Discussionmentioning

confidence: 99%

Could a structural damage mimic a Parkinson plus syndrome?

Alexoudi

Zalonis²,

Stathis³

2013

Open Medicine

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AbstractCorticobasal syndrome (CBS) is a progressive disease that includes a heterogeneous neuropathological spectrum. In the majority of cases, corticobasal degeneration (CBD) is the underlying disease. Clinical heterogeneity is reflected in the clinical presentation of the syndrome and consequently misdiagnosis is common. Our case is of interest because the symptoms, the poor response to L-dopa and the I123 Ioflupane CIT SPECT (DAT-SCAN) results were typical for CBD. However, the magnetic resonance imaging appearance suggested the possibility of a disease of vascular etiology. A 63-year-old woman presented in our outpatient clinic with symptoms of progressive clumsiness in the right arm when performing movements demanding fine motor skills, and mild speech difficulties. The brain magnetic resonance imaging (MRI) report described ischemic lesions in the left subcortical parietal areas, in the centrum semiovale, in periventricular white matter, cingulated gyrus bilaterally and moderate ventricle dilatation. A comprehensive neuropsychological study suggested mixed cortical and subcortical involvement. A DAT-SCAN examination showed a diminished dopamine transporter uptake in the left lenticular nucleus, suggesting parkinsonisn. For this patient, CBS-CBD was the most probable diagnosis, whereas vascular CBS was not excluded. This case report illustrates the low diagnostic sensitivity in predicting CBD and the overlap with other related neurodegenerative diseases. Finally, it demonstrates that in CBS, different underlying pathologies can be found at the same individual.

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“…They found that ≈70% had no evidence of degenerative change in their brain and that these patients performed better on memory tasks than the Pittsburgh Compound B-positive patients. 10 …”

Section: Coexistence Of Degenerative and Vascular Changes In Vcimentioning

confidence: 99%

Advances in Vascular Cognitive Impairment

Gorelick

Pantoni

2013

Stroke

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Identification of pure subcortical vascular dementia using ¹¹ C-Pittsburgh compound B

Abstract: SVaD without abnormal amyloid imaging was more common than expected. Patients with SVaD with and without abnormal amyloid imaging differed in clinical and MRI features, although there was considerable overlap.

Cited by 174 publications

References 25 publications

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

Could a structural damage mimic a Parkinson plus syndrome?

Advances in Vascular Cognitive Impairment

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Identification of pure subcortical vascular dementia using 11 C-Pittsburgh compound B

Abstract: SVaD without abnormal amyloid imaging was more common than expected. Patients with SVaD with and without abnormal amyloid imaging differed in clinical and MRI features, although there was considerable overlap.

Cited by 174 publications

References 25 publications

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden

Could a structural damage mimic a Parkinson plus syndrome?

Advances in Vascular Cognitive Impairment

Contact Info

Product

Resources

About

Identification of pure subcortical vascular dementia using ¹¹ C-Pittsburgh compound B