Identification of purinergic receptors in retinal ganglion cells

Wheeler‐Schilling, Thomas H.; Marquordt, Katja; Köhler, Konrad; Guenther, Elke; Jabs, Ronald

doi:10.1016/s0169-328x(01)00160-7

Cited by 87 publications

(43 citation statements)

References 13 publications

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“…These include the horizontal cells, the short range amacrine cells AII, the long range dopaminergic amacrine cells, as well as all the non-cholinergic cells in the GCL (mostly retinal ganglion cells at these ages), notwithstanding most of these latter cells express the P2X 7 receptors (Fig. 5A) (Wheeler-Schilling et al, 2001). These results indicate that P2X 7 expression is not enough to make cells vulnerable to e-ATP-induced death, in line with previous results showing that susceptibility to ATP may depend on the level of expression of the P2X 7 receptors and the potential coupling of these receptors to cytoplasmic effectors (North, 2002).…”

Section: Discussionmentioning

confidence: 97%

Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control

et al. 2005

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The precise assembly of neuronal circuits requires that the correct number of pre- and postsynaptic neurons form synaptic connections. Neuronal cell number is thus tightly controlled by cell death during development. Investigating the regulation of cell number in the retina we found an ATP gated mechanism of neuronal death control. By degrading endogenous extracellular ATP or blocking the P2X7 ATP receptors we found that endogenous extracellular ATP triggers the death of retinal cholinergic neurons during normal development. ATP-induced death eliminates cholinergic cells too close to one another, thereby controlling the total number, the local density and the regular spacing of these neurons.

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Section: Discussionmentioning

confidence: 97%

Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control

et al. 2005

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“…P2Y2 receptors have been identified in a wide variety of ocular cell types, particularly, in retina [26], retinal pigment epithelium [27][28][29], cornea [30,31], conjunctiva [32], lens [33], and ciliary epithelia [9,34]. P2Y2 receptor signaling and its function are apparent in the eye [35], and regulates multiple cellular functions in ocular physiology by calcium mobilization [9] including ion transport and fluid absorption [27,29], and mucin discharge [36].…”

Section: Discussionmentioning

confidence: 99%

Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells

Kim

Park

Sohn

et al. 2011

Korean J Physiol Pharmacol

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“…However, several lines of evidence support the presence of the receptor in retinal ganglion cells. The molecular analysis of individual ganglion cells described above did not depend on a single antibody [4]. Western blots from the retina of adult rats stained a band of the predicted 70 kD [8].…”

Section: Localization Of P2x 7 Receptor To Retinal Ganglion Cellsmentioning

confidence: 96%

“…mRNA for the P2X 7 receptor was initially identified in the whole rat retina [3]. Subsequently, message for the P2X 7 receptor was demonstrated to be present in material isolated from single ganglion cells with a patch pipette [4]. This implied that P2X 7 receptors were present at the molecular level in individual ganglion cells.…”

Section: Localization Of P2x 7 Receptor To Retinal Ganglion Cellsmentioning

confidence: 99%

The P2X7 receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance

Mitchell

et al. 2009

Purinergic Signalling

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Retinal ganglion cells process the visual signal and transmit it along their axons in the optic nerve to the brain. Molecular, immunohistochemical, and functional analyses indicate that the majority of retinal ganglion cells express the ionotropic P2X 7 receptor. Stimulation of the receptor can lead to a rise in intracellular calcium and cell death, although death does not involve the opening of a large diameter pore. Adenosine acting at A 3 receptors can attenuate the rise in calcium and death accompanying P2X 7 receptor activation, suggesting that dephosphorylation of ATP into adenosine is neuroprotective and that the balance of extracellular purines can influence neuronal survival. Increased intraocular pressure can lead to release of excessive extracellular ATP in the retina and damage ganglion cells by acting on P2X 7 receptors, implicating a role for the receptor in the loss of ganglion cell activity in glaucoma. In summary, the activation of P2X 7 receptors has both physiologic and pathophysiologic implications for ganglion cell function. These characteristics may also provide an insight into the contributions the P2X 7 receptor makes to neurons elsewhere.

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Identification of purinergic receptors in retinal ganglion cells

Cited by 87 publications

References 13 publications

Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control

Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control

Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells

The P2X7 receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance

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