Identification of radiolysis products of solid thiamphenicol

Physicochemical Stability of Space Medicines

“…Similarly, various drugs from different classes such as metoprolol, Magdalena ketoprofen, amoxicillin, doxorubicin, and itraconazole have exhibited chemical stability after 25 kGy radiation in various studies indicating safety of the radiation sterilization process (Kabir et al 1970;Katušin-Ražem et al 2005;Varshney and Dodke 2004;Dettlaff et al 2015;Ogrodowczyk et al 2013). Various articles are also available showing probable degradation profiles of drugs after radiosterilization, but, articles showing the comparison of radiodegradation profile with photodegradation or stress degradation are scarce (Hasanain et al 2014;Ogrodowczyk et al 2018;Dettlaff et al 2014Dettlaff et al , 2015Zeegers et al 1997;Marciniec et al 2010). Eplerenone have shown formation of different degradation products compared to photodegradation after high-energy electron beam radiation at 50-400 kGy dose though total percentage degradation was within pharmacopoeial limits (Dettlaff et al 2014).…”

A Review Solid Stated : Principles and Methode

“…Hal ini dilakukan untuk menentukan konstanta dielektri, temperatur curie dan frekuensi dari bahan. Karakterisasi sampel dapat dilakukan menggunakan alat LCR ( inductor capasitor resistor ) dan STA ( simultaneous thermal analysis ) (80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93)(94)(95) Gambar 1. Neraca Digital (96) Gambar di atas merupakan contoh dari neraca yaitu neraca digital yang dapat digunakan dalam metode solid stated pada proses penimbangan sampel.…”

Molecular perspectives on solid-state phase transformation and chemical reactivity of drugs: metoclopramide as an example

“…The use of g-ray radiation is a method of sterilization for APIs and final dosage forms [105,106]; however, a major problem is that new radiolytic products can be generated [107,108]. Therefore, radiation-sterilized pharmaceutical dosage forms must be examined to determine whether degradation products have been formed.…”