Identification of Ras, MAP kinases, and a GAP protein in 

<i>Schistosoma mansoni</i> by immunoblotting and their putative 

involvement in male–female interaction

Schüssler, P; Grevelding, Christoph G.; Kunz, Werner

doi:10.1017/s003118209700173x

Cited by 53 publications

(27 citation statements)

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“…Orthologs of EGFR and IR [28][29][30] (described below) as well as components of the Ras/MAP kinase pathway have been characterized in the trematode S. mansoni and in the cestode E. multilocularis. Biochemical evidence has been provided that Ras, MAP kinase and the Ras-interacting GAP proteins are developmentally regulated in S. mansoni and possibly involved in male-directed maturation of female parasites [31]. The S. mansoni Ras protein (SmRas) was then shown to be similar to K-Ras from diverse species [32,33].…”

Section: Rtk and Ras/map Kinase Signalling Pathways In Parasitesmentioning

confidence: 99%

Growth factor receptors in helminth parasites: Signalling and host–parasite relationships

et al. 2006

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Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host-derived signal molecules for its development. Recent progress has been made in the characterization of growth factor receptors of various nematode and flatworm parasites with the demonstration that transforming growth factor beta (TGF-b), epidermal growth factor (EGF) and insulin receptor signalling pathways are conserved in helminth parasites and potentially implicated in the host-parasite molecular dialogue and parasite development.

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Section: Rtk and Ras/map Kinase Signalling Pathways In Parasitesmentioning

confidence: 99%

Growth factor receptors in helminth parasites: Signalling and host–parasite relationships

et al. 2006

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“…It is now clear that the ability of S. mansoni to survive for decades in the blood-stream of its host and the sexual maturation of the female that depends on a close contact with the male are processes that require molecular communication (Schussler et al 1997, Kunz 2001, Kapp et al 2004.…”

Section: S Mansoni Proteins Involved In Signal Transductionmentioning

confidence: 99%

Protein tyrosine kinases in Schistosoma mansoni

Bahia

Andrade

Ludolf

et al. 2006

Mem. Inst. Oswaldo Cruz

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The identification and description of signal transduction molecules and mechanisms are essential to elucidate Schistosoma mansoni host-parasite interactions and parasite biology. This mini review focuses on recent advancements in the study of signalling molecules and transduction mechanisms in S. mansoni, drawing special attention to the recently identified and characterised protein tyrosine kinases of S. mansoni.

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“…Molecular studies have finally demonstrated that the male even governs the transcriptional activity of female-specific genes expressed in the reproductive organs, such as those encoding eggshell precursor proteins [25]. During this early time of molecular research on male-female interaction first evidence was obtained that signal transduction cascades could be involved in the control of such processes [26].…”

Section: Introductionmentioning

confidence: 99%

Protein Kinases as Potential Targets for Novel Anti-Schistosomal Strategies

Beckmann

Leutner²,

Gouignard³

et al. 2012

cpd

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Schistosome parasites are the causative pathogens of schistosomiasis (bilharzia), a disease of worldwide significance. In terms of patient numbers, schistosomiasis ranks second to malaria as a parasitosis affecting more than 200 million people of the tropics and subtropics. Since the 1970s Praziquantel (PZQ) is the drug of choice and nearly exclusively used for treatment. However, drug resistance is an increasing threat, particularly with respect to large-scale PZQ administration programs. Last decade´s research indicated that resistance against PZQ can be induced under laboratory conditions, and field studies provided first indications for the possibility of reduced PZQ efficacy. Furthermore, clear evidence for the molecular armamentarium of schistosomes with multidrug transporters was found, one of which was responding to PZQ challenge. Also the development of a vaccine still represents an elusive goal, although effort and time have been invested in this subject. In light of these facts it is commonly accepted that new drugs are urgently needed. Research on signal transduction processes in Schistosoma mansoni has provided an unexpected and novel perspective towards this end. Molecular, biochemical, and physiological studies elucidating principles of schistosome development have demonstrated the essential role of protein kinases (PKs). In humans, PKs are known to be involved in cancer development. Since a variety of approved anticancer drugs targeting PKs exist, first studies have been performed to investigate whether these drugs are able to also inhibit schistosome PKs. Indeed, promising results have been obtained indicating the potential of PKs as privileged targets for new concepts in fighting schistosomes.

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Identification of Ras, MAP kinases, and a GAP protein in Schistosoma mansoni by immunoblotting and their putative involvement in male–female interaction

Cited by 53 publications

References 0 publications

Growth factor receptors in helminth parasites: Signalling and host–parasite relationships

Growth factor receptors in helminth parasites: Signalling and host–parasite relationships

Protein tyrosine kinases in Schistosoma mansoni

Protein Kinases as Potential Targets for Novel Anti-Schistosomal Strategies

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