Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones

Wang, Bohan; Wei, Jingchao; Huangfu, Qi; Gao, Fei; Qin, Lanxin; Zhong, Jie; Wen, Jiaming; Ye, Zhangqun; Yang, Xiaoqi; Liu, Haoran

doi:10.1155/2022/4345037

Cited by 8 publications

(9 citation statements)

References 40 publications

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“…Cholesterol accumulation increases plasma membrane stability and protects cells from further toxic damage ( Zager et al, 1999 ). However, if left unchecked, these initially beneficial effects may increase the risk of kidney stones ( Taguchi et al, 2020 ; Wang et al, 2022 ) and progressive renal injury ( Kim et al, 2009 ; Zager et al, 2011 ). In addition, it is reported that renal tubular cell injury is mediated by lipid accumulation associated with changes in gene expression related to cholesterol transport and synthesis ( Kim et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid

Liu

Zhou

et al. 2022

Front. Pharmacol.

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Background: Urolithiasis or kidney stones is a common and frequently occurring renal disease; calcium oxalate (CaOx) crystals are responsible for 80% of urolithiasis cases. Phyllanthus niruri L. (PN) has been used to treat urolithiasis. This study aimed to determine the potential protective effects and molecular mechanism of PN on calcium oxalate-induced renal injury.Methods: Microarray data sets were generated from the calcium oxalate-induced renal injury model of HK-2 cells and potential disease-related targets were identified. Network pharmacology was employed to identify drug-related targets of PN and construct the active ingredient-target network. Finally, the putative therapeutic targets and active ingredients of PN were verified in vitro and in vivo.Results: A total of 20 active ingredients in PN, 2,428 drug-related targets, and 127 disease-related targets were identified. According to network pharmacology analysis, HMGCS1, SQLE, and SCD were identified as predicted therapeutic target and ellagic acid (EA) was identified as the active ingredient by molecular docking analysis. The increased expression of SQLE, SCD, and HMGCS1 due to calcium oxalate-induced renal injury in HK-2 cells was found to be significantly inhibited by EA. Immunohistochemical in mice also showed that the levels of SQLE, SCD, and HMGCS1 were remarkably restored after EA treatment.Conclusion: EA is the active ingredient in PN responsible for its protective effects against CaOx-induced renal injury. SQLE, SCD, and HMGCS1 are putative therapeutic targets of EA.

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Section: Introductionmentioning

confidence: 99%

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid

Liu

Zhou

et al. 2022

Front. Pharmacol.

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“…Diseases (reference) Lipoxins ischemic stroke, (115) Alzheimer's disease, (116) multiple sclerosis, (117) gram-negative bacterial pneumonia, (118) pneumococcal pneumonia, (119) allergic rhinitis and asthma, (100) hyperalgesia, (120) periodontitis (121) Resolvin E1 Alzheimer's disease, (116) myocardial infarction, (122) depression, (123) asthma, (124) inflammatory bowel disease, (125) herpes simplex virus-induced ocular inflammation, (126) psoriatic dermatitis, (127) contact hypersensitivity of skin (128) Resolvin D1 depression, (129) emphysema, (130) E. coli-induced pneumonia, (118) pneumococcal pneumonia, (119) non-alcoholic steatohepatitis, (131) kidney stones, (132) diabetic wounds, (133) oral squamous cell carcinoma (134) Maresin Alzheimer's disease, (135) cerebral ischemia/reperfusion injury, (136) asthma, (137) inflammatory bowel disease, (130) diabetic nephropathy, (138) skin inflammation by UVB (139) Protectins epilepsy, (140) influenza infection, (106) kidney stones, (132) wound healing (141) cult. On the other hand, if the mechanism of 5-LOX activation by daidzein is elucidated and compounds that accelerates the production of lipid mediators via induction of LOX activity are developed, they may become new therapeutic agents for influenza.…”

Section: Mediatorsmentioning

confidence: 99%

Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment

Shichiri

Suzuki

Isegawa

et al. 2023

J. Clin. Biochem. Nutr.

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Although many diseases in which reactive oxygen species (ROS) and free radicals are involved in their pathogenesis are known, and antioxidants that effectively capture ROS have been identified and developed, there are only a few diseases for which antioxidants have been used for treatment. Here, we discuss on the following four concepts regarding the development of applications for disease treatment by regulating ROS, free radicals, and lipid oxidation with the findings of our research and previous reports. Concept 1) Utilization of antioxidants for disease treatment. In particular, the importance of the timing of starting antioxidant will be discussed. Concept 2) Therapeutic strategies using ROS and free radicals. Methods of inducing ferroptosis, which has been advocated as an iron-dependent cell death, are mentioned. Concept 3) Treatment with drugs that inhibit the synthesis of lipid mediators. In addition to the reduction of inflammatory lipid mediators by inhibiting cyclooxygenase and leukotriene synthesis, we will introduce the possibility of disease treatment with lipoxygenase inhibitors. Concept 4) Disease treatment by inducing the production of useful lipid mediators for disease control. We describe the treatment of inflammatory diseases utilizing pro-resolving mediators and propose potential compounds that activate lipoxygenase to produce these beneficial mediators.

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“…The LC-MS/MS for LMs has been reported previously 27 . Brie y, LMs was analyzed byd by LC-MS/ MS using a Shimadzu LC-20ACXR (Shimadzu, Kyoto, Japan) and Sciex 5500 triple quadruple mass spectrometer (Sciex, MA, USA) with heated electrospray ionization (ESI).…”

Section: Lc-ms/ms For Lipid Mediatorsmentioning

confidence: 99%

Lipid mediator profiling of serum in children with H1N1 infection

Chen,

Gu,

et al. 2023

Preprint

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H1N1 virus can cause severe acute respiratory distress syndrome, and death in young children and the elderly. The H1N1 infection initiates the inflammatory responses that are directed toward containment and elimination of microbial invaders. Because various lipid mediators (LMs) are biosynthesized and play a critical role in fighting against the virus during inflammation, profiling the LMs in patients may uncover the disrupted pathways and reveal mechanistical insights of diseases. To date, little is known about the LM molecular alterations and pathogenesis of H1N1 in children. Here, we employed a targeted LC-MS/MS platform to map serum LM profiles from children with H1N1 and after recovery. We found that 22 LM species have changed in H1N1 children with mild symptoms. Analysis of LM profiles of children with recovery revealed that the level of 12 altered LM species in H1N1 infection were partially restored, including cytochrome P450 (CYP) enzyme-derived DIHETEs and HETEs from AA, and EpOMEs from LA, whereas PGs are decreased. Taken together, this study established a link between serum lipid mediators and H1N1 infection in children with mild symptoms. The LM species dramatically altered in H1N1-children could serve as potential therapeutics or adjuvants against H1N1 influenza.

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Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones

Cited by 8 publications

References 40 publications

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid

Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment

Lipid mediator profiling of serum in children with H1N1 infection

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