2021
DOI: 10.7717/peerj.11350
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Identification of robust diagnostic and prognostic gene signatures in different grades of gliomas: a retrospective study

Abstract: Background Gliomas are the most common primary tumors of the central nervous system. The complexity and heterogeneity of the tumor makes it difficult to obtain good biomarkers for drug development. In this study, through The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA), we analyze the common diagnostic and prognostic moleculer markers in Caucasian and Asian populations, which can be used as drug targets in the future. Methods … Show more

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“…Despite the continued discovery of genes relevant to glioma prognosis 27 and the development of emerging therapies, the improvement in patient prognosis has been limited and the treatment outcome for some glioma patients has been suboptimal 28 . For three decades, most of the clinical strategies have functioned by targeting tumor cells to induce apoptosis 29 .…”
Section: Discussionmentioning
confidence: 99%
“…Despite the continued discovery of genes relevant to glioma prognosis 27 and the development of emerging therapies, the improvement in patient prognosis has been limited and the treatment outcome for some glioma patients has been suboptimal 28 . For three decades, most of the clinical strategies have functioned by targeting tumor cells to induce apoptosis 29 .…”
Section: Discussionmentioning
confidence: 99%