Identification of salivary metabolites for oral squamous cell carcinoma and oral epithelial dysplasia screening from persistent suspicious oral mucosal lesions

Ishikawa, Shinya; Wong, David T.; Sugimoto, Masahiro; Gleber‐Netto, Frederico O.; Li, Feng; Tu, Manghui; Zhang, Yong; Akin, David; Iino, Mitsuyoshi

doi:10.1007/s00784-018-2777-3

Cited by 33 publications

(29 citation statements)

References 33 publications

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“…A more recent study also found salivary metabolomics could separate lichen planus from oral cancer, finding discriminatory metabolites upregulated in oral cancer included indoleacetate, putrescine and phosphoethanolamine [51]. Oral cancer and precancerous dysplasia have also been separated from other clinically similar lesions including keratosis and inflammation [52].…”

Section: Current Knowledge Of the Salivary Metabolomementioning

confidence: 97%

Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function

2020

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Metabolomic profiling of biofluids, e.g., urine, plasma, has generated vast and ever-increasing amounts of knowledge over the last few decades. Paradoxically, metabolomic analysis of saliva, the most readily-available human biofluid, has lagged. This review explores the history of saliva-based metabolomics and summarizes current knowledge of salivary metabolomics. Current applications of salivary metabolomics have largely focused on diagnostic biomarker discovery and the diagnostic value of the current literature base is explored. There is also a small, albeit promising, literature base concerning the use of salivary metabolomics in monitoring athletic performance. Functional roles of salivary metabolites remain largely unexplored. Areas of emerging knowledge include the role of oral host–microbiome interactions in shaping the salivary metabolite profile and the potential roles of salivary metabolites in oral physiology, e.g., in taste perception. Discussion of future research directions describes the need to begin acquiring a greater knowledge of the function of salivary metabolites, a current research direction in the field of the gut metabolome. The role of saliva as an easily obtainable, information-rich fluid that could complement other gastrointestinal fluids in the exploration of the gut metabolome is emphasized.

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Section: Current Knowledge Of the Salivary Metabolomementioning

confidence: 97%

Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function

2020

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“…Solo application of prospective sampling without blinded evaluation resulted in a high risk of bias in 62.5% of studies (Appendix B). The patient selection domain also had the greatest proportion of studies with high applicability concerns as a result of investigating biomarkers for the detection of OSCC recurrence or distant metastases, head and neck lymphomas, severe epithelial dysplasia, and metaplasia dyskeratosis in addition to primary OSCC diagnosis 17,18,21,22 …”

Section: Resultsmentioning

confidence: 99%

“…All studies reported that squamous carcinomas of the head and neck results in a higher serum l ‐fucose level than precancerous or healthy states; however, the sensitivity observed in the single study reporting quantitative measures of efficacy was moderate 19 . For salivary metabolomic biomarkers, Ishikawa and colleagues 22 suggested that the combination of ornithine, O ‐hydroxybenzoate, and ribose‐5‐phosphate had a high discriminatory power in delineating oral carcinomas and high‐grade oral dysplasia from other persistent suspicious oral mucosal lesions.…”

Section: Resultsmentioning

confidence: 99%

“…The patient selection domain also had the greatest proportion of studies with high applicability concerns as a result of investigating biomarkers for the detection of OSCC recurrence or distant metastases, head and neck lymphomas, severe epithelial dysplasia, and metaplasia dyskeratosis in addition to primary OSCC diagnosis. 17,18,21,22 3.3 | Range and nature of fluid-phase biomarkers…”

Section: Methodological Considerationsmentioning

confidence: 99%

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Mock clinical testing in the validation of fluid‐phase biomarkers for head and neck carcinoma diagnosis: Scoping review

2020

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This review sought to determine the range and nature of prospective-sampling and blinding methods for validating nonviral biofluid markers diagnostic of head and neck carcinomas. Electronic database searching was conducted to identify studies published in English from January 1, 2009 to August 1, 2020. Sixteen studies from 17 articles published between 2011 and 2020 were included in this review. We found that about 3 out of 100 studies utilized at least one of the mock testing approaches for biomarker validation. Protein, mRNA, and metabolomic markers also represented the only groups whose validation has been attempted using these methods. Furthermore, studies that utilized both methods were found to have lower bias concerns on the quality assessment of diagnostic accuracy studies (QUADAS-2) tool. Overall, there is a need to include these protocols in research endeavours verifying diagnostic biomarkers for head and neck carcinomas following the preliminary establishment of their classification accuracy.

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“…In addition, the combination of priopionyl choline, N‐acetyl‐L‐phenylalanine, sphinganine, phytosphingosine and S‐carboxymethyl‐L‐cysteine also offer excellent sensitivity and specificity . Recent investigations have proposed altered levels of s‐adenosylmethionine + pipecolinic acid, and the combination of ornithine, o‐hydroxybenzoate and ribose‐5‐phosphate may be early diagnostic markers for OSCC . Other candidate markers such as lactate, proline, glycine, citrulline, inositol trisphosphate, 2‐oxoarginine and glycerate‐2‐phosphate have all been proposed as putative markers for future validation studies …”

Section: Metabolomic Biomarker Combinationsmentioning

confidence: 99%

“Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection

Adeoye

Brennan

Thomson

2020

J Oral Pathology Medicine

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Oral squamous cell carcinoma is one of the commonest head and neck malignancies with approximately 350 000 cases reported annually and a mortality rate of 50% often attributed to late clinical presentation. Due to the close relationship between saliva bio‐fluid and tumour lesions, optimizing salivary biomarkers for disease detection and screening provides a major new research direction in diagnostic oral oncology. As inter‐tumour heterogeneity and intra‐tumour heterogeneity are common within oral cavity neoplasms, it is unlikely that a single diagnostic or “risk‐stratifying” saliva biomarker will suffice for universal translation to clinical practice. Therefore, this article highlights a number of promising saliva biomarker combinations for oral cavity cancer detection that require further research and validation to determine their true diagnostic potential.

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Identification of salivary metabolites for oral squamous cell carcinoma and oral epithelial dysplasia screening from persistent suspicious oral mucosal lesions

Cited by 33 publications

References 33 publications

Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function

Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function

Mock clinical testing in the validation of fluid‐phase biomarkers for head and neck carcinoma diagnosis: Scoping review

“Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection

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