Identification of Secondary Metabolites with Antioxidant and Antimicrobial Activities from Artemisia iwayomogi and Chrysanthemum zawadskii

Shin, Seungwon; Lee, Yeonhee; Moon, Su Ran; Koo, In Hye; Hong, Hyunjin; Shin, Eunju; Lee, Minyoung; Park, Jihye; Chung, Ha Sook

doi:10.3839/jksabc.2010.108

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…The 80% ethanol extract was partitioned successively with n-hexane, chloroform, ethyl acetate, and n-butanol and the fractions were tested for biological activity. The active ethyl acetate-soluble fraction was purified trough repeated column chromatography to yield five compounds, characterized based on EI-MS, UV, IR, and NMR spectral data [ 104 ].…”

Section: Methods Of Analysis Of Sesquiterpene Lactonesmentioning

confidence: 99%

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Ivănescu

Miron

Corciovă

2015

Journal of Analytical Methods in Chemistry

155

118

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Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.

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Section: Methods Of Analysis Of Sesquiterpene Lactonesmentioning

confidence: 99%

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Ivănescu

Miron

Corciovă

2015

Journal of Analytical Methods in Chemistry

155

118

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“…The roots of N. nucifera have been identified as being rich in dietary fiber, vitamins B1, B2, B6 and C, potassium, phosphorus, copper and manganese (10). N. nucifera contains biologically effective flavonoids, including kaempferol, quercetin, rutin and hyperoside, exhibits anti-inflammatory, -oxidant, -fungal, -microbial and tyrosinase inhibitory activities, and has protective properties in carbon tetrachloride-induced liver damage (11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells

Guon

Chung

2016

Oncology Letters

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Abstract. The present study demonstrates the mechanism of 2 flavonol glycosides, hyperoside and rutin, in the induction of apoptosis in HT-29 human colon cancer cells through the bioactivity-guided fractionation and isolation method. The chemical structure of hyperoside and rutin, isolated from the roots of Nelumbo nucifera, were established using extensive 1-and 2-dimensional nuclear magnetic resonance experiments and absolute high resolution fast-atom bombardment mass spectrometry, ultraviolet-visible and Fourier transform infrared spectroscopy spectral analytical methods. The treatment of HT-29 colon cancer cells with hyperoside and rutin significantly decreased cell viability in a dose-dependent manner. The concomitant activation of the mitochondria-dependent apoptotic pathway of hyperoside and rutin occurred via modulation of Bcl-2-associated X protein and B-cell lymphoma 2 expression, resulting in the activation of cleaved caspases-3, -8 and -9 and cleaved poly-(ADP-ribose) polymerase. The findings of the present study indicate that hyperoside and rutin induce apoptosis in HT-29 human colon cancer cells, and that this phenomenon is mediated via the death receptor-mediated and mitochondria-mediated apoptotic pathways. These results suggest that hyperoside and rutin may be useful in the development of a colon cancer therapy protocol.

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“…Chrysanthemum zawadskii Herbich (Asteraceae: Asteroideae), is a native plant in Korea (Park et al 2020 ) and has economic values as traditional medicinal resources (Shin et al 2010 ) and ornamental plants (Kim et al 2014 ). There was controversy over its scientific name; Chrysanthemum L. and Dendranthema (DC.)…”

mentioning

confidence: 99%

The complete chloroplast genome of Chrysanthemum zawadskii Herbich (Asteraceae) isolated in Korea

BAEK

Park²,

Lee³

et al. 2021

Mitochondrial DNA Part B

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We have determined the complete chloroplast genome of Chrysanthemum zawadskii Herbich isolated in Korea. The circular chloroplast genome of C. zawadskii is 151,137 bp long and has four subregions: 83,041 bp of large single copy and 18,350 bp of small single copy regions are separated by 24,873 bp of inverted repeat regions including 133 genes (87 protein-coding genes, eight rRNA genes, 37 tRNAs, and one pseudogene). There are 65 to 152 single nucleotide polymorphisms and 33 to 64 insertion and deletion regions (178 bp to 372 bp in length) identified against three available chloroplast genomes of C. zawadskii . The phylogenetic tree shows that C. zawadskii is clustered as a paraphyletic group with C. zawadskii subsp. coreanum , displaying incongruency between species and clades.

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Identification of Secondary Metabolites with Antioxidant and Antimicrobial Activities from Artemisia iwayomogi and Chrysanthemum zawadskii

Cited by 8 publications

References 22 publications

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Hyperoside and rutin of Nelumbo nucifera induce mitochondrial apoptosis through a caspase-dependent mechanism in HT-29 human colon cancer cells

The complete chloroplast genome of Chrysanthemum zawadskii Herbich (Asteraceae) isolated in Korea

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