Identification of serological markers for pre- and postoperative fasting periods

Wuensch, Tilo; Quint, J; Mueller, Verena; Mueller, Anne; Wizenty, Jonas; Kaffarnik, Magnus; Kern, Barbara; Stockmann, Martin; Biebl, Matthias; Pratschke, Johann; Aigner, Felix

doi:10.1016/j.clnesp.2019.01.004

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…They should be monitored for possible adverse effects caused by WF, such as: increased uric acid and creatinine blood concentrations, decreased glomerular filtration, or other serious health complications. 8 , 9 Ketosis, which develops from the first days of fasting, is its metabolic consequence. In the early days of starvation, which is considered a mild and stable state, ketone bodies are an alternative source of energy substrates for the nervous system and other body cells, the metabolism of which depends on glucose.…”

Section: Introductionmentioning

confidence: 99%

Is Water-Only Fasting Safe?

Ogłodek

Pilis

2021

Glob Adv Health Med

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Background Water-only fasting (WF) is a practice used to improve and maintain health. Objective The aim of the study was to show whether WF performed for 8 days may be a threat to the health and/or life of people undergoing this practice. Methods Twelve middle-aged men participated in the study. During the 8-day WF, the subjects ate no food except for drinking mineral water. Before and after WF, all subjects had a series of tests performed, beginning with the level of perceived stress and somatic measurements. The concentrations of creatinine, sodium (Na+), potassium (K+), total calcium (Ca), magnesium (Mg++), urea (U), uric acid (UA) and total protein were determined in this urine and in the serum. For these substances, the values of clearance, renal filtration and fractional excretion were calculated. The osmotic clearance and free water clearance as well as the amount of daily urinary excretion of creatinine, Na+, K+, Ca, Mg++, U and UA were also calculated. Moreover, the concentration of glucose in the serum and the concentration of β-hydroxybutyrate in the plasma were determined. In urine, specific gravity, pH and osmolality were also measured. Results After 8 days of WF, the study showed a significant reduction in the level of perceived stress, weight loss, changes in body composition, dehydration, increased ketogenesis, hyperuricemia, decreased serum glucose concentration, and hyponatremia. These changes were accompanied by Na+, K+ and protein sparing, decreased serum Ca and Mg++ concentrations, and reduced daily volume of more acidic urine with elevated specific gravity. Conclusions After 8 days of WF, all subjects were found to remain safe and feel the sense of well-being. However, the appearance of the above-mentioned adverse metabolic effects, despite partially effective renal compensations, suggests that the further continuation of fasting intervention by the subjects would be detrimental to their body.

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Section: Introductionmentioning

confidence: 99%

Is Water-Only Fasting Safe?

Ogłodek

Pilis

2021

Glob Adv Health Med

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Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

Berg

Taudorf

Bailey

et al. 2019

Scandinavian Journal of Clinical and Laboratory Investigation

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Tempo de jejum e alterações metabólicas em cirurgias eletivas: revisão integrativa

et al. 2021

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Objetivo: identificar na produção científica a ocorrência de alterações metabólicas no pós-operatório de cirurgias eletivas e sua relação com o tempo de jejum no pré operatório. Método: revisão integrativa, realizada de junho a julho de 2020 nas bases de dados LILACS, MEDLINE, CINAHL, COCHRANE, SCOPUS e EMBASE. Foram selecionados artigos de 2015 a 2020. Para a análise dos níveis de evidência seguiu-se a categorização de Oxford Centre for Evidence-Based Medicine. Resultados: foram selecionados 10 artigos científicos. As alterações metabólicas encontradas foram hiperglicemia, elevação dos níveis séricos de IL-6, cortisol e valina, aumento da resistência insulínica, queda dos níveis plasmáticos de ácido glutâmico e elevação dos níveis de IGF-1 com a redução de IGFBP-3. A abreviação do tempo de jejum minimiza o estresse orgânico ao paciente, com a redução das alterações metabólicas, tempo de internação e morbidade. Conclusão: o tempo de jejum pré-operatório superior a oito horas está relacionado...

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Identification of serological markers for pre- and postoperative fasting periods

Cited by 3 publications

References 42 publications

Is Water-Only Fasting Safe?

Is Water-Only Fasting Safe?

Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

Tempo de jejum e alterações metabólicas em cirurgias eletivas: revisão integrativa

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