1994
DOI: 10.1006/viro.1994.1202
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Identification of Serotype-Specific and Nonserotype-Specific B-Cell Epitopes of Coxsackie B Virus Using Synthetic Peptides

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Cited by 38 publications
(23 citation statements)
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“…When the PV type 1 is attached to the cell surface, the amino terminus of subsided VP1 is exposed and may be available for the host immune recognition. Similar conformational changes are observed in non-polio enteroviruses when these viruses infect humans (4,8,10). Furthermore, VP1 of PV is antigenic to B cells and CD4 ϩ T cells and induces neutralizing antibodies in mice and rabbits (7,19).…”
Section: Discussionmentioning
confidence: 62%
“…When the PV type 1 is attached to the cell surface, the amino terminus of subsided VP1 is exposed and may be available for the host immune recognition. Similar conformational changes are observed in non-polio enteroviruses when these viruses infect humans (4,8,10). Furthermore, VP1 of PV is antigenic to B cells and CD4 ϩ T cells and induces neutralizing antibodies in mice and rabbits (7,19).…”
Section: Discussionmentioning
confidence: 62%
“…Previous studies have shown that three synthetic peptides based on the sequence of VP1 of CVB3 can identify the serotype-specific and non-serotype-specific Bcell epitopes of coxsackieviruses (7). In that study, three peptides were characterized, showing that peptide VP1-1, representing residues 1-15 of VP1, is highly type-specific for CVB3; peptide VP1-3 (residues 21-35 of VP1) is a non-type-specific antigenic determinant of CVB3; and peptide VP1-24 (residues 229-243 of VP1) is broadly cross-reactive with all coxsackievirus-derived sera, except anti-CVB1 sera.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, VP2 has an antigenic neutralizing region, termed the "puff region," which is present on the exterior of the virus capsid and is one of the protein regions in poliovirus that line the rim of the canyon floor (6,9,12,15). However, it is principally accepted that, among the four capsid proteins, VP1 has the major antigenic determinants (7).…”
mentioning
confidence: 99%
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“…The P1 region encodes four structural proteins: VP1, VP2, VP3, and VP4. VP1 is the major antigenic determinant of CVB3 and is the most external and immunodominant of its capsid proteins (1). CVB3 can cause meningoencephalitis (2), acute pancreatitis (3), and childhood-onset diabetes (4,5).…”
mentioning
confidence: 99%